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CD Biosynsis is your specialized CRO partner for agricultural biotechnology. We engineer microbial chassis, optimize metabolic pathways, and develop fermentation processes to help agriculture industry and research teams bring novel biological products from concept to pilot scale.
Serving the Agricultural Biotechnology Ecosystem
Research Institutions
Academic partnerships
Agribusiness
Crop input companies
Seed Companies
Trait integration partners
Biotech Startups
Innovation collaborators
End-to-end infrastructure for agricultural biological development
CRISPR-Cas9, base editing, and directed evolution for precise genetic modification
De novo metabolic pathway construction and flux optimization for target compounds
Fermentation optimization from shake flask to pilot scale with media design
Comprehensive metabolite profiling, stability testing, and quality control
The agriculture industry faces unique challenges that traditional chemistry struggles to resolve. Our synthetic biology platform offers precision-engineered biological solutions targeting the root causes of agriculture industry inefficiencies.
Over-reliance on synthetic nitrogen fertilizers causes soil acidification, groundwater nitrate contamination, eutrophication of waterways, and represents a significant portion of operational costs for commercial farms. Our nitrogen-fixing microbial inoculants can replace a substantial percentage of synthetic inputs while advancing your ESG commitments.
Hundreds of pest species have developed resistance to chemical pesticides. Our RNAi-based biopesticides and engineered biocontrol agents utilize novel modes of action that pests and pathogens cannot easily evolve resistance against.
Drought, salinity, and temperature extremes reduce global crop yields significantly each year. We engineer plant growth-promoting microbes that activate stress-response pathways, maintaining productivity under abiotic stress conditions.
Platform Approach
40% faster development
We provide specialized microbial engineering services for agriculture applications. From chassis strain development to metabolic pathway optimization, our team delivers sequence-confirmed, functionally validated strains ready for your downstream development pipeline.
We engineer optimized host strains for agricultural applications. Our platforms include Pseudomonas, Bacillus, and yeast, with particular expertise in rhizosphere bacteria—key partners in plant-microbe symbiosis and nutrient cycling.
De novo design and optimization of biosynthetic pathways for agricultural metabolites. We balance precursor supply, reduce competing pathways, and tune enzyme expression levels to achieve industrially relevant titers.
Engineering diazotrophic bacteria for enhanced nitrogenase activity and host compatibility. Our platform supports development of non-leguminous crop symbionts—the "holy grail" of agricultural synthetic biology—enabling nitrogen fixation in cereals like corn and wheat.
Microbial cell factories for agriculturally relevant natural products including antimicrobial peptides, siderophores, and volatile organic compounds. We optimize secretion systems and reduce toxicity to host cells.
Scale-up support from shake flask to pilot bioreactor. We optimize media composition, feeding strategies, and process parameters to maximize biomass and product yield for your engineered strains.
Comprehensive analytical packages to validate your engineered strains. Genomic confirmation, metabolite profiling, stability testing, and phenotypic assays to ensure your strain meets specifications.
Why the agriculture industry is transitioning to engineered biological solutions.
| Parameter | Chemical Inputs | Synthetic Biology |
|---|---|---|
| Environmental Impact | Soil degradation, water contamination | Biodegradable, soil health positive |
| Resistance Development | High (3-5 years average) | Minimal (novel MOA) |
| Regulatory Pathway | Complex, lengthy re-registration | Consulting on regulatory pathways |
| Cost Trajectory | Rising input costs | Scalable, decreasing marginal cost |
| Worker Safety | PPE required, re-entry intervals | Generally recognized as safe (GRAS) |
Integrated molecular biology, analytical chemistry, and bioprocess capabilities to deliver sequence-confirmed, functionally validated strains for your agricultural biotechnology pipeline.
CRISPR-Cas9, base editing, recombineering, and Gibson assembly. Automated colony picking and high-throughput strain construction.
LC-MS/MS and GC-MS metabolite profiling. Targeted quantification of pathway intermediates and final products for strain optimization.
Shake flask to bioreactor scale-up. DoE-based media optimization, fed-batch development, and process analytical technology (PAT).
Genome mining, pathway prediction, enzyme selection algorithms, and metabolic flux modeling to guide rational strain design.
We function as your external strain engineering and metabolic pathway team. Whether you need a single engineered chassis or a complete pathway optimization pipeline, we deliver publication-quality data and transfer-ready strains.
Each project is assigned a dedicated PhD-level scientist as primary contact, ensuring technical continuity and rapid decision-making throughout development.
Engage us for full end-to-end development or specific phases (strain engineering only, fermentation optimization only, etc.). Scale investment according to your validation needs.
All proprietary strains and sequences remain your exclusive property. We offer clean IP transfer with no residual license claims or downstream revenue sharing requirements.
In-house regulatory affairs team experienced with EPA, EFSA, USDA-APHIS, and OECD guidelines. We prepare submission-ready dossiers for your target markets.
Concept to pilot validation. Includes strain engineering, fermentation optimization, and greenhouse testing.
Genetic modification and characterization. Deliverables include sequence-confirmed strains and technical reports.
Process development and optimization. From lab-scale proof to pilot-scale production parameters.
Characterization, stability testing, and regulatory dossier preparation for submission.
Get answers to common questions about our agriculture solutions. our team for project-specific inquiries.
Prepare your host organism (or desired chassis), target metabolic pathway or genetic modification, expected phenotype, and any specific selection markers or regulatory constraints. Include your preferred deliverables (plasmids, frozen stocks, sequence data) and timeline. Our scientists will review and provide a technical feasibility assessment within 24 hours.
A typical chassis strain engineering project takes 8-12 weeks from design to sequence-confirmed strain. Metabolic pathway optimization projects typically require 4-6 months including iterative rounds of screening and validation. Complex de novo pathway construction may extend to 8-10 months. We provide weekly progress updates and hold monthly video review meetings.
We execute comprehensive NDAs before any technical discussion. All strains, sequences, and data generated during the project are your exclusive property. We provide complete sequence files, strain deposition certificates, and raw analytical data. No residual license claims or downstream revenue sharing. Clean IP transfer upon project completion.
We work with both Gram-negative and Gram-positive bacteria as well as yeast platforms. Common agricultural chassis include Pseudomonas putida, Bacillus subtilis, and Saccharomyces cerevisiae. We specialize in rhizosphere bacteria—Azospirillum, Herbaspirillum, and other plant growth-promoting rhizobacteria (PGPR)—for maximum agricultural impact. Our team will recommend the optimal chassis based on your target product, secretion needs, and regulatory pathway.
Regulatory classification depends on your final product and modification approach. We can engineer strains using methods that may qualify for streamlined review (e.g., self-cloning, site-directed mutagenesis). Our regulatory team provides guidance on EPA FIFRA, USDA-APHIS, and EFSA requirements during the project design phase to ensure your strain aligns with your intended regulatory pathway.
Get a customized quote for your Agriculture project. Our experts will respond within 24 hours.
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.