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Strain Engineering for Natural Rubber

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CD Biosynsis is committed to providing a basis for the modification of biosynthetic pathways in natural rubber through high-throughput multi-omics data analysis.

Introduction of Synthetic Biology-Driven Natural Rubber Biosynthesis

Natural rubber, usually extracted from gum-bearing plants, is an irreplaceable and highly valuable biopolymer. Natural rubber has unique physical properties, including high resilience, impact and abrasion resistance, heat dissipation, and ductility at low temperatures, which are only important for transportation, pharmaceutical, and defense industries. Currently, natural rubber is produced exclusively from rubber trees, and the increasing demand for natural rubber has inspired scientists to explore synthetic biology methods that can replace rubber trees in the production of natural rubber

Model of the natural rubber biosynthetic machinery. (Yamashita S, et al., 2020)Figure 1. Model of the natural rubber biosynthetic machinery. (Yamashita S, et al., 2020)

What We Provide

Featured Services

  • We are able to use transgenic technology. Use of Hevea brasiliensis latex plants to produce high value-added natural organics.
  • We can provide genomic, transcriptomic and proteomic analysis services to provide a comprehensive understanding of natural rubber synthesis.
  • We are able to regulate the activity of enzymes that play a role in the biosynthesis of natural rubber, providing guidance for the modification of biological chassis for the production of natural rubber.


  • Natural rubber.

How We Can Help

Development of Genetically Engineered Microbial for Natural Rubber Production

The synthesis of natural rubber includes the initiation of rubber molecule formation, the extension of rubber molecule chains, and the termination of rubber molecule synthesis. Each step is regulated by the enzymatic activity of rubber biosynthesis. We are able to construct a gene that encodes an amino acid sequence identical to that of a plant enzyme, which can be optimized for engineered microorganisms.

Regulation of Natural Rubber Biosynthesis

Rubber biosynthesis is regulated by the activity of enzymes involved in rubber biosynthesis, including 3-hydroxy-3-methylglutaryl coenzyme, isopentenyl pyrophosphate isomerase, rubber transferase, etc. We are able to regulate the production of natural rubber by regulating the activity of the above enzymes.

Applications of Natural Rubber

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive natural rubber production and meet the needs of customers in a variety of industries.

  • For the preparation of surgical gloves.
  • For the preparation of golf balls.
  • For the preparation of adhesives.
  • For the preparation of tires.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in natural rubber production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.


  1. Yamashita S, Takahashi S. Molecular Mechanisms of Natural Rubber Biosynthesis. Annu Rev Biochem. 2020 Jun 20; 89: 821-851.

Please note that all services are for research use only. Not intended for any clinical use.

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