Serine is an amino acid currently used in the cosmetics, pharmaceutical, and medical industry. The estimated annual production of serine is between 300–1,000 tons (Leuchtenberger et al., 2005). Additionally, the compound has been identified as one of the top 30 most interesting building block biochemical, because of its potential industrial uses (Werpy et al., 2004). If the production cost can be reduced, a significantly larger market may therefore open up. The current production is based on conversion of glycine and methanol using resting cells (Hagishita et al., 1996), where methylotrophs convert methanol to formaldehyde and transfer the CH2-OH unit of the molecule to glycine using serine hydroxymethyltransferase (glyA). In this process, around 90% of glycine supplied is converted to serine, taking 5 days to complete. Glycine is significantly more expensive than glucose leading to a high production cost of L-serine.
Serine Biosynthesis Service is a specialized and comprehensive offering provided by our company that focuses on the production and modification of serine, an essential amino acid, through advanced engineering techniques. With a deep understanding of the serine biosynthesis pathway and expertise in strain engineering, our service aims to provide cutting-edge solutions for various applications in the field of biotechnology and pharmaceutical research.
The serine biosynthesis pathway is a complex metabolic pathway that plays a fundamental role in the synthesis of serine. Serine is a vital building block for various biological processes and is essential for the growth and development of living organisms. The pathway involves a series of enzymatic reactions that convert precursor molecules into serine. By comprehensively understanding and manipulating this pathway, we can optimize serine production through strategic strain engineering and metabolic engineering approaches. This enables us to design and develop microbial strains that are highly efficient in converting precursors into serine, leading to enhanced production yields and overall process efficiency.
Schematic representation of metabolic pathways involved in the construction of a serine producing E. coli strain
Serine Biosynthesis Service Strain Engineering is a crucial component of our Serine Biosynthesis Service. It involves the genetic modification and optimization of microbial strains to enhance their serine production capabilities. Through the utilization of state-of-the-art techniques and leveraging our extensive expertise, we can engineer strains that exhibit significantly improved productivity, efficiency, and yield in serine biosynthesis. By fine-tuning the genetic makeup of these strains, we can unlock their full potential for serine production, enabling our clients to achieve their desired outcomes more effectively.
Our Serine Biosynthesis Service has a broad range of applications across various industries and research fields, making it a versatile solution for diverse needs. Some of the key areas where our service can be applied include:
We would be delighted to explore potential cooperation opportunities with you. Please feel free to contact us at your convenience to discuss further details and collaboration possibilities. We look forward to hearing from you.
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.