CD Biosynsis is able to integrate genomic, proteomic, and metabolomic data using genetic, metabolic, and enzymatic engineering tools to develop and optimize microbial synthetic pathways for 3-hydroxypropionic acid. We offer customized synthetic biology services designed to help our customers achieve efficient biosynthesis of 3-hydroxypropionic acid.
Advantages of Synthetic Biology-Driven 3-Hydroxypropionic Acid Production
3-Hydroxypropionic acid is an important platform chemical raw material. 3-Hydroxypropionic acid can be used as an important chemical intermediate for the production of acrylic acid, acrylamide, malonic acid, 3-hydroxypropionic acid polymer, etc. Currently, 3-hydroxypropionic acid is produced by chemical synthesis. However, the chemical synthesis method has disadvantages such as high technical difficulty and environmental pollution. Synthetic biology is able to synthesize 3-hydroxypropionic acid using substrates such as glucose and glycerol, and this method has the advantages of simple operation, low production cost, and environmental friendliness.
Figure 1. Strategies for high-level production of 3-hydroxypropionic acid. (Zhao P, et al., 2021)
What We Provide
Optimization of Fermentation Conditions
We are able to help our customers optimize the method of 3-hydroxypropionic acid separation and purification, and simplify the pathway of 3-hydroxypropionic acid production. We help our customers minimize the by-products of 3-hydroxypropionic acid production by optimizing the fermentation conditions.
Genetic Engineering
We can use genetic engineering tools to increase the growth rate and tolerance to acidic environments of microbial cells in 3-hydroxypropionic acid synthesis medium.
Multi-omics Analysis
We are able to integrate genomics, proteomics, and metabolomics into the design, construction, and testing of 3-hydroxypropionic acid biosynthesis systems to improve the yield of 3-hydroxypropionic acid.
Deliverables
- Efficient cell factory for 3-hydroxypropionic acid production.
- 3-hydroxypropionic acid.
How We Help
Currently, the biosynthesis of 3-hydroxypropionic acid mainly uses glucose and glycerol as substrates. Based on the synthetic biology platform, CD Biosynsis is able to provide optimization services for the natural synthetic pathway of 3-hydroxypropionic acid. If the following services do not meet your requirements, please contact us directly and we look forward to working with you.
Optimum the 3-Hydroxypropionic Acid Production Pathway from Glucose
The shortest pathway for the synthesis of 3-hydroxypropionic acid using glucose as a substrate is the malonyl-CoA pathway. We are able to promote the synthesis of 3-hydroxypropionic acid by enhancing metabolic flux, enhancing cofactors, and inducing point mutations in the genes encoding.
Optimum the 3-Hydroxypropionic Acid Production Pathway from Glycerol
Glycerol is inexpensive and there are natural pathways in many microorganisms that rely on it to produce 3-hydroxypropionic acid. Based on our synthetic biology platform, we are able to help our customers to realize microbial chassis development and optimization services for the synthesis of 3-hydroxypropionic acid microsomes using glycerol as a substrate.
The following are microbial chassis that have been successfully or are under development for 3-hydroxypropionic acid biosynthesis.
| Escherichia coli |
Corynebacterium glutamicum |
Aspergillus |
| Lactobacillus roxellanae |
Hansenula miso |
Fusarium |
| merismoides |
Candida rugosa |
Byssochlamys sp. |
| Klebsiella pneumoniae |
Synechococcus elongatus |
|
Applications of 3-Hydroxypropionic Acid
CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive 3-hydroxypropionic acid production and meet the needs of customers in a variety of industries.
- Used as an intermediate for the production of 1,3-propanediol.
- Used as a platform chemical for the production of acrylic acid.
- Used as a raw material for bio-polyester.
- Used as a nematocide.
Want to Learn More?
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.
Reference
- Zhao P, et al. Biosynthesis pathways and strategies for improving 3-hydroxypropionic acid production in bacteria. World J Microbiol Biotechnol. 2021 Jun 15; 37(7): 117.
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