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Strain Engineering for Ethylene Glycol

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CD Biosynsis can help customers design ethylene glycol production pathways that rely on renewable resources, based on a synthetic biology platform, and using metabolic and genetic engineering tools. We expect to help our customers achieve efficient production of ethylene glycol in microorganisms through the design and optimization of metabolic pathways for ethylene glycol biosynthesis.

Advantages of Synthetic Biology-Driven Ethylene Glycol Production

Ethylene glycol is a pass-through chemical, mainly used in the production of polyester fiber, antifreeze, etc. Currently, the industrial production of ethylene glycol is entirely dependent on petrol. The steam cracking of petrol produces ethylene, which is oxidized to produce ethylene oxide. Ethylene oxide is then thermally hydrolyzed to produce ethylene glycol. However, the decreasing availability of petrol and rising market prices make industrial production of ethylene glycol a huge challenge. Finding strategies to develop ethylene glycol based on renewable resources is important to alleviate fossil energy endangerment. Synthetic biology enables the production of ethylene glycol from renewable energy sources.

Figure 1. Biosynthetic routes for ethylene glycol production in recombinant bacteria based on pentose assimilation pathways. (Uranukul B, et al., 2019)Figure 1. Biosynthetic routes for ethylene glycol production in recombinant bacteria based on pentose assimilation pathways. (Uranukul B, et al., 2019)

What We Provide

Based on our synthetic biology platform, we are able to help our customers achieve microbiological production of ethylene glycol.

Metabolic Pathway Synthesis and Optimization

We are able to use metabolic engineering strategies to modify the metabolic pathways of microorganisms to improve the yield of ethylene glycol.

Genetic Engineering

By analyzing the metabolic pathways of microbial ethylene glycol synthesis, we can use genetic engineering tools to regulate the expression of metabolic enzymes to help our customers optimize ethylene glycol synthesis strains.

Pathway Design

We are able to help our customers design metabolic pathways for the synthesis of glycols based on certain biomasses.


  • Efficient cell factory for ethylene glycol production.
  • Ethylene glycol.

How We Help

Production of ethylene glycol from D-xylose

We are able to regulate or design the metabolic pathway of D-xylose, using genetic engineering tools to overexpress or knock out genes encoding enzymes that play a key role in the pathway of D-xylose to produce ethylene glycol. Ultimately, we can help our customers to realize the production of glycols from xylose as raw material in E. coli or Saccharomyces cerevisiae.

Production of ethylene glycol from glucose

We are able to use metabolic engineering tools to assemble endogenous and exogenous enzymes from microorganisms and design glucose-dependent ethylene glycol production pathways.

Applications of Ethylene Glycol

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive ethylene glycol production and meet the needs of customers in a variety of industries.

  • As a viable alternative to dimethyl sulfoxide in applications where dimethyl sulfoxide has disadvantages.
  • Used as water blocker of rechargeable aqueous zinc batteries.
  • Hydrogen production from ethylene glycol.
  • Application in the production of glyoxal, glycolic acid, and methyl glycolate.
  • Ethylene glycol is capable of synthesizing monodisperse metal nanocrystals.
  • Ethylene glycol can be used for the induction of nephritis in rats.

Want to Learn More?

As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.


  1. Uranukul B, et al. Biosynthesis of monoethylene glycol in Saccharomyces cerevisiae utilizing native glycolytic enzymes. Metab Eng. 2019 Jan; 51: 20-31.  

Please note that all services are for research use only. Not intended for any clinical use.

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