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Engineering of Phage Chassis for Biosynthesis

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CD Biosynsis has hands-on experience and knowledge of phage engineering to help customers develop well-characterized synthetic biology chassis to broaden the applications of phages. Our scientists are exploring ways to engineer phages as a versatile chassis for developing novel tools for fundamental research, drug development, diagnosis and beyond.


Engineering of Phage Chassis for Synthetic Biology

Bacteriophages or phages, as the most abundant organisms on earth, constitute a vast reservoir of unexplored genes and proteins. The biological nature of phages makes them relatively easy to isolate and propagate. As an essential player in biology, phages have also contributed greatly to the development of synthetic biology. The phage genomes are important biological parts for constructing synthetic genetic circuits. Rapid advances in biotechnology, such as molecular biology and sequencing, have enabled efficient and precise phage engineering, especially of poorly characterized phages. The genomics diversity of phages suggests that there are many useful functions yet to be discovered. With the discovery of new families of phages, synthetic biologists are expected to discover more exciting possibilities for phages.

What We Can Do

CD Biosynsis has many years of experience in the isolation, propagation, characterization, and engineering of phages. Our synthetic biologists are dedicated to the development of genetic elements and the rational design and construction of synthetic phages using a range of enabling technologies to enhance or modify the natural properties of phages. We combine phage-based technologies with synthetic biology tools to achieve enhanced phage infection efficacy and host range modification.

Engineering of Phage Chassis for Synthetic Biology – CD Biosynsis

Phage-Based Applications

Based on our efficient phage engineering strategies and advanced synthetic biology toolbox, CD Biosynsis can help our customers develop phage chassis in a fast turnaround time, paving the way for the development of diverse applications for phages. Our scientists will work closely with our customers to fully exploit the biotechnological and therapeutical potential of different types of phages.

Phage Group Nucleic Acid Type Examples
Myoviridae Linear dsDNA Enterobacteria phage T4
Siphoviridae Linear dsDNA Enterobacteria phage λ
Podoviridae Linear dsDNA Enterobacterial phage T7
Tectivitidae Linear dsDNA Enterobacteria phage PRD1
Rudiviridae Linear dsDNA Sulfolobus islandicus rod-shaped virus 2 (SIRV2)
Lipothrixviridae Linear dsDNA Thermoproteus tenax virus 1 (TTV1)
Guttaviridae Circular dsDNA Sulfolobus newzealandicus droplet-shaped virus (SNDV)
Corticoviridae Circular dsDNA Pseudoalteromonas phage PM2
Fuselloviridae Circular dsDNA Sulfolobus spindle-shaped virus 1 (SSV1)
Plasmaviridae Enveloped circular dsDNA Acholeplasma phage L2
Inoviridae Circular ssDNA Enterobacteria phage M13
Microviridae Circular ssDNA Enterobacteria ΦX174
Cystoviridae Enveloped segmented dsRNA Pseudomonas phage φ6
Leviviridae Linear ssRNA Enterobacteria phage MS2
  • Phage display
  • Phage-assisted continuous evolution
  • Phage-based in situ microbiome engineering
  • Phage-based detection of pathogens
  • Engineered bacteriophage lysins as antibacterials
  • Phages as DNA delivery shuttles
  • Phage-based delivery of CRISPR-Cas system
  • Phage-based drug delivery systems
  • Phage-based vaccine development
  • Phage-based diagnostics
  • Phage-based nanomaterials
  • Enhanced phage therapy against multidrug-resistant pathogens
  • Biofilm degradation

Want to Learn More?

CD Biosynsis has been continuously expanding our synthetic biology toolbox and keeping our knowledge and skills current. We provide full support for our customers' innovations in synthetic biology. If you require any further details, please feel free to contact us and let us know how we can support your new idea or project.


  1. Lemire S, et al. Phage-based applications in synthetic biology. Annual Review of Virology, 2018, 5: 453-476.
  2. Huss P & Raman S. Engineered bacteriophages as programmable biocontrol agents. Current Opinion in Biotechnology, 2020, 61: 116-121.

Please note that all services are for research use only. Not intended for any clinical use.

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