Trusted by Leading Research & Pharma Institutions

Synthetic Biology Test Services

Accelerate strain characterization and phenotype validation with our advanced high-throughput screening platforms. From FACS-based sorting to droplet microfluidics and multi-parameter plate assays, we deliver comprehensive testing solutions that power your Design-Build-Test-Learn cycles.

FACS & Microfluidics

Multi-Omics Analysis

Automated Phenotyping

Explore Services

Trusted by leading research and pharmaceutical institutions

Harvard

Pfizer

MIT

Roche

Stanford

Novartis

Advanced Screening

High-Throughput Screening Capabilities

FACS Sorting

Up to 10⁷ cells/second throughput

Droplet Microfluidics

Picoliter-scale screening at 10⁸ droplets/second

Plate-Based Assays

Automated 384/1536-well format

Comprehensive Testing Solutions

High-Throughput Screening for the DBTL Cycle

Our Test services provide comprehensive high-throughput screening capabilities that enable rapid phenotyping and characterization of engineered biological systems. From single-cell sorting to population-level analysis, we deliver the data you need to close the Design-Build-Test-Learn cycle efficiently.

Fluorescence-Activated Cell Sorting

FACS enables high-throughput screening of millions of cells based on fluorescent markers. Ideal for strain selection, pathway optimization, and protein engineering applications.

Multi-parameter sorting (up to 18 colors)
Single-cell deposition capability
Sterile sorting for viable cells

Droplet Microfluidics

Droplet-based screening platforms enable ultra-high-throughput screening of enzyme variants, secreted products, and cell-free systems at picoliter scale.

10⁸ droplets/second generation rate
Uniform droplet size distribution
Compatible with various substrates

Automated Plate Assays

High-density plate screening with automated liquid handling for detailed kinetic measurements and multi-parameter characterization of biological variants.

384 and 1536-well formats
Automated dispensing and reading
Time-resolved fluorescence support

Advanced Technologies

State-of-the-Art Screening Platforms

Our screening infrastructure combines multiple detection modalities with advanced automation to deliver comprehensive phenotyping data across diverse biological systems.

Flow Cytometry & FACS

Advanced flow cytometry platforms enabling multi-parameter analysis and high-speed cell sorting for diverse applications including strain selection and protein engineering.

Up to 18-color panels 10⁷ cells/sec sorting Single-cell deposition

Droplet Microfluidics

Droplet-based screening systems for ultra-high-throughput enzyme evolution, metabolic screening, and cell-free expression optimization.

Picoliter-scale screening 10⁸ droplets/sec Encapsulation efficiency

Plate-Based Screening

Automated high-density plate handling with integrated detection systems for kinetic measurements, growth profiling, and metabolite quantification.

384/1536-well formats Multi-mode readers Automated liquid handling

Biosensor Development

Custom biosensor engineering including genetically encoded fluorescent reporters, FRET-based sensors, and cell-free transcription-translation systems.

Genetically encoded sensors FRET-based detection Cell-free compatible

Screening Technology Comparison

Technology	Throughput	Readout
FACS	10⁷ cells/sec	Fluorescence
Droplet Microfluidics	10⁸ droplets/sec	Various
Plate Screening	10³-10⁴ wells	Multi-parameter
Flow Cytometry	10⁴ cells/sec	Multi-color

Technology selection depends on your specific screening goals and biological system. Our team can help design the optimal screening strategy.

Service Specifications

Screening Service Parameters

Comprehensive testing capabilities with flexible configuration options to meet your specific research requirements.

FACS Services

Sorting speed: up to 10⁷ cells/second
Multi-parameter analysis: up to 18 colors
Single-cell deposition into 96/384-well plates
Sterile and non-sterile sorting modes
Population purity verification

Droplet Services

Droplet generation: 10⁸ droplets/second
Uniform size distribution (CV less than 5%)
Oil-water emulsion systems
FACS-compatible droplet sorting
Custom fluorogenic substrates

Plate Assays

Format: 96, 384, and 1536-well plates
Absorbance, fluorescence, luminescence detection
Time-resolved fluorescence capability
Automated dispensing and aspiration
Kinetic endpoint measurements

Biosensor Services

Custom promoter-reporter fusions
Metabolite biosensor development
Genetically encoded calcium indicators
FRET-based molecular sensors
Cell-free sensor validation

Analytical Services

Metabolite quantification (LC-MS, GC-MS)
Proteomics and transcriptomics
Flow cytometry phenotyping
Next-generation sequencing support
Statistical analysis and data processing

Custom Solutions

Tailored screening assay development
Novel biosensor engineering
Integrated DBTL workflow design
Automation platform integration
Scale-up consultation

Custom Specifications Available

Our team can develop custom screening protocols and assays tailored to your specific biological system and research objectives. Contact us to discuss your unique requirements.

Service Process

Our Screening Workflow

A streamlined process designed to deliver high-quality screening data efficiently and reproducibly.

Consultation

Initial discussion to understand your screening goals, biological system, and data requirements. We review your strain libraries and define appropriate controls.

Goal alignment
Technology selection
Protocol design

Assay Development

Custom assay development and optimization, including biosensor engineering, detection method validation, and pilot testing with representative samples.

Biosensor design
Signal optimization
Z-factor validation

High-Throughput Screening

Large-scale screening execution with rigorous quality control, including positive/negative controls on each plate, replicate validation, and real-time monitoring.

Automated execution
QC metrics
Hit identification

Data Analysis

Comprehensive data analysis including statistical processing, hit ranking, clustering analysis, and integration with downstream characterization workflows.

Statistical analysis
Hit validation
Reporting

Use Cases

Applications of Our Screening Services

Our high-throughput screening platforms support diverse applications across metabolic engineering, protein engineering, and synthetic biology research.

Metabolic Pathway Optimization

High-throughput screening of strain libraries for improved production of fuels, chemicals, and pharmaceuticals. FACS-based sorting of strains carrying biosensor outputs.

Strain Selection Titer Improvement

Enzyme Engineering

Ultra-high-throughput screening of enzyme variant libraries using droplet microfluidics. Identification of improved catalysts for industrial and therapeutic applications.

Directed Evolution Enzyme Optimization

Genetic Circuit Characterization

Multi-parameter flow cytometry analysis of genetic circuit performance across large variant libraries. Quantitative characterization of promoter and RBS strengths.

Circuit Design Parts Characterization

Protein-Protein Interactions

FRET-based and split-reporter screening for identification and optimization of protein-protein interactions. Membrane protein and antibody engineering support.

PPI Screening Antibody Engineering

Therapeutic Development

Cell-based screening for identification of therapeutic leads, mechanism of action studies, and cytotoxicity profiling. Support forCAR-T and immune cell engineering.

Drug Discovery Cell Engineering

Biosensor Development

Engineering and characterization of genetically encoded biosensors for metabolite detection, stress response monitoring, and pathway performance readout.

Metabolite Sensing Reporter Development

Client Feedback

Trusted by Leading Research Teams

Hear from researchers who have accelerated their DBTL cycles with our screening services.

"The droplet microfluidics screening service enabled us to screen over 10 million enzyme variants in a single day. This accelerated our directed evolution project significantly."

Research Lead

Metabolic Engineering Lab

"Their FACS capabilities and custom biosensor development helped us identify high-producing strains with unprecedented precision. The data quality exceeded our expectations."

Principal Investigator

Industrial Biotechnology

"Working with their team on assay development was seamless. They understood our biological system and delivered a screening protocol that provided actionable data immediately."

Senior Scientist

Synthetic Biology Startup

Common Questions

Frequently Asked Questions

Find answers to common questions about our high-throughput screening services.

What screening technologies do you offer?

We offer a comprehensive suite of high-throughput screening technologies including fluorescence-activated cell sorting (FACS), droplet microfluidics, and automated plate-based assays. Each platform is optimized for specific applications and can be combined with custom biosensor development for specialized screening needs.

What is the typical screening throughput?

Throughput varies by platform: FACS can process up to 10⁷ cells per second, droplet microfluidics can generate up to 10⁸ droplets per second, and plate-based screening supports 384-well and 1536-well formats with automated handling. The appropriate technology depends on your specific screening goals and biological system.

Can you develop custom biosensors for my pathway?

Yes, we offer custom biosensor development services. Our team can engineer genetically encoded fluorescent reporters, FRET-based sensors, and cell-free compatible detection systems tailored to your specific metabolites or cellular outputs. We validate all biosensors before deployment in screening campaigns.

What controls are included in screening campaigns?

Every screening campaign includes appropriate positive and negative controls on each plate, technical replicates, and Z-factor validation to ensure assay quality. We also provide statistical analysis support to help interpret screening results and identify high-confidence hits.

Do you offer downstream hit validation?

Yes, we provide comprehensive hit validation including re-screening of top hits, counter-screening for false positives, and secondary assays using orthogonal detection methods. We also offer integration with our Build and Learn services for full DBTL cycle support.

What biological systems do you support?

We support screening in bacterial systems (E. coli, Bacillus), yeast (S. cerevisiae, P. pastoris), mammalian cells (CHO, HEK293), and plant protoplasts. Our platforms can be adapted for cell-free systems as well.

How do I get started with a screening project?

Start by scheduling a consultation with our team. We'll discuss your screening goals, biological system, strain library size, and detection requirements. Based on this information, we'll recommend the optimal screening platform and develop a custom assay protocol for your project.

What data formats are provided?

We provide comprehensive data packages including raw instrument files (FCS, HDF5), processed data tables (CSV, Excel), statistical analysis reports, and visualization-ready plots. All data can be integrated with your LIMS or ELN system.

Ready to Start Your Project?

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Expert consultation

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Synthetic Biology Test Services

High-Throughput Screening Capabilities

FACS Sorting

Droplet Microfluidics

Plate-Based Assays

High-Throughput Screening for the DBTL Cycle

Fluorescence-Activated Cell Sorting

Droplet Microfluidics

Automated Plate Assays

Ready to Accelerate Your Screening Workflows?

State-of-the-Art Screening Platforms

Flow Cytometry & FACS

Droplet Microfluidics

Plate-Based Screening

Biosensor Development

Screening Technology Comparison

Screening Service Parameters

FACS Services

Droplet Services

Plate Assays

Biosensor Services

Analytical Services

Custom Solutions

Custom Specifications Available

Our Screening Workflow

Consultation

Assay Development

High-Throughput Screening

Data Analysis

Applications of Our Screening Services

Metabolic Pathway Optimization

Enzyme Engineering

Genetic Circuit Characterization

Protein-Protein Interactions

Therapeutic Development

Biosensor Development

Trusted by Leading Research Teams

Frequently Asked Questions

What screening technologies do you offer?

What is the typical screening throughput?

Can you develop custom biosensors for my pathway?

What controls are included in screening campaigns?

Do you offer downstream hit validation?

What biological systems do you support?

How do I get started with a screening project?

What data formats are provided?

Ready to Start Your Project?

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