CD Biosynsis is dedicated to the development and optimization of synthetic pathways for glutaric acid based on synthetic biology platforms, and the search for glutaric acid production technologies with short fermentation cycles, high conversion rates and high yields.
Glutaric acid is an important C5 platform chemical that serves as a synthetic precursor chemical for a variety of value-added C5 derivatives. Glutaric acid has been widely used in chemical, pharmaceutical, and agricultural applications. Currently, the synthesis of glutaric acid is mainly based on the oxidation of highly aromatic compounds such as cyclohexanol and cyclopentanol, and the nitric acid oxidation of 2-cyanocyclopentanone. The above-mentioned pathways for the synthesis of glutaric acid usually require extreme reaction conditions and produce toxic substances. However, the production of synthetic biologically driven glutaric acid mainly utilizes microbial fermentation and enzyme catalysis. Thus, the production of glutaric acid using synthetic biology techniques can not only be carried out under milder conditions but also be a green and sustainable process.
Figure 1. Multiple engineering strategies for constructing efficient glutaric acid cell factories. (Uranukul B, et al., 2019)
Based on our synthetic biology platform, we are able to help our customers achieve microbiological production of glutaric acid.
We are able to help our customers improve the production of glutaric acid in target strains by establishing and improving the glutaric acid biosynthesis pathway.
We are able to construct recombinant strains with the ability to accumulate high levels of glutaric acid using tools such as promoter libraries, mRNA stability, and ribosome binding site modulation.
Establishment of Metabolic Pathways for Biosynthesis of Glutaric Acid
The biosynthetic pathways of glutaric acid mainly include α-ketoglutarate reduction, transadipate degradation, α-ketoglutarate carbon chain extension and decarboxylation, 5-aminoglutarate pathway and cadaveric pathway. We are able to use genetic engineering and metabolic engineering tools to modulate the glutaric acid biosynthetic pathway to increase glutaric acid production. The specific services we are able to provide are as follows and include but are not limited to.
Optimization of Whole Cell Reaction Condition
Substrates, intermediate metabolites, by-products, products, temperature, pH, etc. can all affect the production of glutaric acid. We are able to help our customers establish optimal whole-cell catalytic systems.
CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive glutaric acid production and meet the needs of customers in a variety of industries.
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.