CD Biosynsis

Deep learning and de novo design synthesis of highly efficient luciferase that does not exist in nature

For the first time, a brand new enzyme was designed from scratch using AI, which can achieve ultra-high performance and unlimited quantity

1 day ago04 mins

Organisms use enzymes to decompose or synthesize substances under mild conditions, often without relying on toxic compounds or extreme high temperature conditions, making them known as “perfect chemists”. However, due to the complexity and variability of enzyme reaction mechanisms, designing their synthesis is one of the most challenging tasks in biochemistry. On February 22nd, David…

The Development Roadmap of Enzyme Rational Design, Nature: The Path to Fully Programmable Protein Catalysis

1 day ago1 day ago019 mins

Enzymes are a class of highly functional biocatalysts that catalyze chemical reactions through complex active sites, greatly accelerating the reaction process and providing unparalleled selectivity. With the advancement of technologies such as DNA synthesis and sequencing, bioinformatics, and computational modeling, more and more natural enzymes with specific catalytic functions have been discovered. These enzymes have…

Utilizing evolutionary diffusion for protein generation, Microsoft’s open-source new protein generation AI framework EvoDiff

1 day ago1 day ago014 mins

Evolution has produced multiple functional proteins that can precisely regulate cellular processes. In recent years, deep generation models have emerged, aiming to learn from this diversity and generate both effective and novel proteins, with the ultimate goal of customizing functionality to address today’s prominent challenges. When it comes to creating new proteins on computers,…

Saccharomyces cerevisiae efficiently produces the spice raspberry ketone on a chassis, with the highest reported yield currently

1 week ago08 mins

Raspberry ketone is the main aromatic compound of red raspberry, which has wide applications in cosmetics, food, and medicine. In recent years, raspberry ketone has attracted wide attention as a essence and dietary supplement. However, the natural abundance of raspberry ketone is low, with only 1-4 milligrams extracted from 1 kilogram of raspberry, making…

L-malic acid biosynthesis, the malic acid market is expected to reach a scale of tens of billions by 2031

1 week ago1 week ago07 mins

1) Introduction to L-malic acid Malic acid, also known as 2-hydroxysuccinic acid, has an asymmetric carbon hydroxysuccinic acid in its molecule, which has two stereoisomers and exists in three forms: L-malic acid, DL malic acid, and D-malic acid. It can be widely used in fields such as food and beverage, medicine, and chemical industry. Currently,…

Cell free biosynthesis system

1 week ago1 week ago019 mins

The drawbacks of traditional microbial fermentation processes include the risk of contamination by harmful microorganisms, the inhibitory effect of high concentration carbon sources in the culture medium, microbial thermal sensitivity, and instability. And low yield and productivity, low substrate utilization efficiency, production of by-products and secondary metabolites, or high downstream processing costs. In order to…

Overview of Synthetic Biology

2 weeks ago1 week ago09 mins

The definition of synthetic biology is to use engineering ideas to modularize or create biological cells, enabling them to have the ability to synthesize compounds. Generalized synthetic biology actually refers to the extension of a series of downstream technologies based on DNA editing technology, including microbial metabolic engineering, enzyme engineering, gene editing services, cell therapy…

Summary of Techniques Used in Synthetic Biology

2 weeks ago1 week ago011 mins

In recent years, with the changes in human environment and diseases, the incidence of fungal infections has been increasing year by year. Candida albicans is one of the important pathogens causing fungal infections. In addition, it is also an important food-borne pathogen.

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