Synthetic Biology
Strain Engineering for Globular Protein

Strain Engineering for Globular Protein

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Strain Engineering for Globular Protein

CD Biosynsis leverages our advanced synthetic biology-based technologies and extensive experience to help our customers explore more cost-effective and efficient ways to produce globular proteins. Our dedicated scientists are capable of re-engineering and optimizing the biosynthetic pathways of globular proteins via innovative ideas based on synthetic biology to advance the widespread application of globular proteins.

Advantages of Synthetic Biology-Driven Globular Protein Production

Globular proteins, also known as spheroproteins, are the most abundant proteins in nature, so-called for their approximate spherical shape. Globular proteins are usually very soluble in aqueous solutions and have many different functions, such as enzymes, cellular messengers, and molecular transport proteins. With the increasing demand for globular proteins in the biomedical, pharmaceutical, and food industries, there is an urgent need to develop effective strategies to construct powerful globular proteins and to improve the efficiency and yield of industrial production of globular proteins. Synthetic biology combines engineering thinking with disruptive technologies to help us overcome all the difficulties encountered in the production of globular proteins. The industrialization of synthetic biology-driven microbial production processes and cell-free production systems is also an effective way to reduce the cost of globular protein production.

Figure 1. Leveraging the design-build-test cycle to produce engineered proteins. (Calzini MA, et al., 2021)Figure 1. Leveraging the design-build-test cycle to produce engineered proteins. (Calzini MA, et al., 2021)

What We Provide

CD Biosynsis can customize synthetic biology-based tools and strategies to develop superior functional globular proteins that meet the specific needs of our customers. We are committed to creating efficient and cost-effective methods to produce various types of globular proteins to facilitate their application in a wide range of fields. Our specialized and experienced scientists are available to help our customers solve all difficulties in the production and application of globular proteins.

Genetic Engineering

We used genetic engineering techniques to regulate the expression of genes involved in the amino acid biosynthesis pathway to promote globular protein production.

Metabolic Engineering

We are able to optimize the expression modules of globular proteins such as protease module, molecular chaperone module, pyruvate metabolic pathway module, amino acid biosynthesis pathway module, glycolytic pathway module and tricarboxylic acid cycle module to rationally modify the engineered bacteria.

Precision Fermentation

We are able to optimize the fermentation conditions of the microorganisms, thus increasing the yield of intact globular proteins produced by the microorganisms.


  • Globular proteins-producing microorganisms.
  • Globular protein.

How We Can Help

Development of Synthetic Biology Chassis for Globular Proteins Production

Our genetic and metabolic engineering expertise allows us to help our customers design, build and modify microbial chassis to obtain the desired properties to improve globular protein productivity. We are committed to developing robust and stable globular proteins through creative technologies in synthetic biology. Our dedicated scientists are capable of helping our customers establish large-scale, efficient production microorganisms for globular proteins. The following microbial strains are available for the production of globular proteins. If you are interested in other strains, please fill out the online inquiry form and tell us more about your project.

Aspergillus niger Clostridium thermocellum Nocardia globerula Rhodotorula glutinis Talaromyces thermophilus
Aureobasidium pullulans Debaryomyces hansenii Phanerochaete chrysosporium Serratia marcescens Thermoascus aurantiacus
Bacillus flexus Enterococcus faecium Piromyces rhizinjlata Sporidiobolus pararoseus Thermotoga maritima
Bacillus pallidus Fusarium solani Pseudomonas fluorescens Stachybotrys microspora Trichoderma harzianum
Burkholderia cenocepacia Geobacillus pallidus Pyrococcus abyssi Staphylococcus warneri Trichoderma longibrachiatumi
Burkholderia ubonensis Geotrichum candidum Rhodobacter sphaeroides Stenotrophomonas maltophilia Trichoderma reesei

Synthetic Biology-based Strategies for the Improvement of Globular Protein Production

  • We use engineering concepts based on synthetic biology and genetic engineering techniques to design and reconstruct the biosynthetic pathways of globular proteins to improve the functional properties of globular proteins.
  • We can use a powerful genetic manipulation toolkit to directionally add strong promoters to enhance the expression of globular protein and achieve large-scale, low-cost production of globular protein.
  • Our distinguished scientists apply the concepts of holistic synthetic biology to the engineering of cell-free protein synthesis systems, using advanced synthetic biology tools to enhance synthetic modules and create new platforms for globular protein production.
  • We can use a comprehensive and powerful synthetic biology-based approach to program and modify living cells to create efficient cell factory systems for the production of globular proteins with complex structures and functions, such as immunoglobulins.

Applications of Globular Proteins

Globular proteins are functional proteins that are essential for almost all biochemical reactions in organisms and can be applied in a wide range of fields such as biomedicine, pharmaceuticals, and the food industry. Several applications of globular proteins in related fields are listed below.

  • Used in biological washing.
  • Used in the field of brewing.
  • Used in laboratory research.
  • Used in disease treatment and diagnosis.
  • Used in food processing.
  • Used in the textile industry.
  • Used in CAR-T therapy development.
  • Used in laboratory research.
  • Used in antibody drug development.
  • Used in biochemical reagent development.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in protein and peptide production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.


  1. Grünberg R, Serrano L. Strategies for protein synthetic biology. Nucleic Acids Res. 2010, 38(8): 2663-75.
  2. Yigit S, et al. Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications. Biotechnol Bioeng. 2016, 113(5): 913-29.
Please note that all services are for research use only. Not intended for any clinical use.

Synthetic Biology Applications

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