CD Biosynsis has built an advanced synthetic biology platform with the ability to help our customers achieve breakthroughs in the enhanced microbial production and the cell-free production of butanediol. We combine genetic engineering, metabolic engineering, and cell-free synthetic biochemistry to achieve high titer and high yield production of butanediol to meet the needs of diverse industries.
Butanediol (BDO) with the molecular formula C4H10O2 refers to all the isomers of butylene glycol. BDO is an important organic compound that is widely used in different industries. Petroleum-derived BDO produced from substrates such as acetylene and propylene, is mainly produced via catalytic hydrogenation, which is a tedious and difficult process. Coupled with the instability of these substrates and the fact that the petroleum-based production is a costly process, there is a need to develop a commercial process for the biological production of alternatives to petroleum-derived BDO from renewable resources. The emerging enabling technologies and synthetic biology-inspired strategies allow the redesign, engineering, and optimization of novel biological pathways, enabling the modular development of engineered microorganisms for successful sustainable biological production of butanediol.
Figure 1. Comparison of chemical and biological processes for the production of 2,3-BD. (Song C W, et al., 2019)
Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of butanediol.
CD Biosynsis offers various enabling technologies and tools in synthetic biology to help our customers solve any problems that may arise in the biological production of butanediol. Our scientists are committed to harnessing the power of synthetic biology to achieve high yield, economical and sustainable BDO production.
We have developed a synthetic biology toolbox including a wide range of techniques for different microbial species to help our customers identify key genes and biosynthetic pathways for improved microbial production of BDO. Our scientists can help our customers choose the right host strain for chassis development from the following table. If you are interested in other microbial strains, please fill out the online inquiry form and tell us more about your project.
|Bacillus amyloliquefaciens||Bacillus licheniformis||Bacillus subtilis||Corynebacterium glutamicum||Enterobacter aerogenes|
|Enterobacter cloace||Escherichia coli||Klebsiella oxytoca||Klebsiella pneumoniae||Lactococcus lactis|
|Paenibacillus polymyxa||Saccharomyces cerevisiae||Serratia marcescens||Synechococcus elongatus||Zymomonas mobilis|
We have the ability to help our customers overcome genetic and metabolic engineering challenges of chassis strains. Our advanced computational tools allow for de novo pathway design in engineered microorganisms to enhance BDO production capacity. We can help design and develop microbial cell factories to meet the requirements for large-scale production of butanediol.
Our expertise and experience enable us to develop cell-free systems as an alternative to microbial BDO production. Our multidisciplinary team can help our customers achieve high-yield BDO production by designing synthetic enzyme cascades in cell-free systems.
CD Biosynsis provides customized solutions for synthetic biology-driven butanediol production to meet a wide range of applications from chemical to energy industries.
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.