Synthetic Biology
Home / Services / By Technology / Gene Editing Services / Genome Editing Service / RNA Editing Services
Nobel Prize-Winning Technology

RNA Interference Services

Harness the power of RNAi for precise gene silencing. Our comprehensive RNAi services include siRNA, shRNA, and miRNA solutions for research and therapeutic applications.

High Specificity
Proven Delivery
Therapeutic Grade
Learn More

Trusted by leading research institutions

Harvard
MIT
Stanford
Broad Institute

Why Choose Us

siRNA, shRNA, miRNA options
GalNAc and LNP delivery
Chemical modifications
Research to GMP grade

siRNA

Synthetic 21-23 nt duplexes

shRNA

Vector-based hairpin constructs

miRNA

Mimics and inhibitors

Gene Silencing
>80%
Overview Technology Specifications Workflow Applications FAQ
Service Overview

Precision Gene Silencing with RNA Interference

RNA interference (RNAi) is a powerful biological mechanism for sequence-specific gene silencing, recognized with the 2006 Nobel Prize and now a validated therapeutic modality.

What is RNAi?

RNA interference is a natural cellular process where small RNA molecules guide the RNA-induced silencing complex (RISC) to degrade target mRNA or inhibit translation. This sequence-specific mechanism enables precise gene knockdown without altering the genome.

  • Sequence-specific gene silencing
  • Post-transcriptional regulation
  • No permanent genetic changes

Why Choose Our Service?

We provide comprehensive RNAi services with expert design, high-quality synthesis, and proven delivery technologies. Our team helps you select the optimal RNAi approach and delivery strategy for your specific research or therapeutic goals.

  • Multiple RNAi formats available
  • Advanced delivery technologies
  • Research to GMP grade

High Specificity

Sequence-specific targeting with minimal off-target effects when properly designed.

Proven Delivery

GalNAc and LNP technologies enable efficient delivery to target tissues.

Therapeutic Grade

GMP manufacturing capabilities for clinical development programs.

Ready to Explore RNAi?

Get a customized quote for your RNAi project.

Technology Platform

Comprehensive RNAi Solutions

Multiple RNAi formats and delivery technologies to match your experimental needs.

siRNA

Synthetic 21-23 nucleotide duplexes for rapid, transient gene silencing. Ideal for short-term studies and therapeutic applications.

21-23 nt 3-7 days

shRNA

Vector-expressed hairpin RNAs for stable, long-term gene silencing. Perfect for stable cell line generation and in vivo applications.

50-70 nt Weeks-months

miRNA

Mimics and inhibitors for modulating endogenous miRNA activity. Enable miRNA replacement or inhibition studies.

22 nt Mimic/Inhibit

Delivery Technologies

GalNAc Liver-specific delivery
LNP Broad tissue delivery
C16 CNS delivery
Viral shRNA delivery

Chemical Modifications

2'-OMe Enhanced stability
2'-F Nuclease resistance
PS Backbone stabilization
ESC Enhanced stabilization
Specifications

Flexible Options for Diverse Applications

Comprehensive specifications to meet your research and therapeutic requirements.

Parameter Specification
RNAi Types siRNA, shRNA, miRNA mimics, miRNA inhibitors
siRNA Length 19-25 nucleotides, 2-nt 3' overhangs
Chemical Modifications 2'-OMe, 2'-F, phosphorothioate, LNA
Delivery Systems GalNAc conjugates, LNP, C16, viral vectors
Quality Control Mass spec, HPLC, potency assay, endotoxin
Turnaround Time 2-8 weeks depending on project complexity
Workflow

Streamlined Process from Design to Delivery

Our proven workflow ensures quality and efficiency at every stage.

1

Consultation

Discuss target gene and RNAi approach

2

Design

Sequence design and optimization

3

Synthesis

RNA synthesis and modification

4

QC

Purity and potency verification

5

Delivery

Reagents with comprehensive QC report

Applications

Diverse Applications in Research and Therapeutics

RNAi powers discovery and therapeutic development across multiple fields.

Therapeutic Development

RNAi therapeutics have achieved clinical success with 6 FDA-approved drugs. The approach enables highly specific gene silencing for treating genetic diseases, viral infections, and metabolic disorders.

  • hATTR amyloidosis (patisiran)
  • Acute hepatic porphyria (givosiran)
  • Hypercholesterolemia (inclisiran)
  • Hemophilia (fitusiran)
6
FDA-approved RNAi drugs

Functional Genomics

RNAi enables high-throughput gene function analysis, pathway mapping, and target validation. Genome-wide libraries allow systematic screening for genes involved in disease processes.

  • Gene function studies
  • Pathway analysis
  • Drug target validation
  • Genome-wide screening
Genome-wide
Screening capabilities

Agricultural Applications

RNAi enables crop improvement through gene silencing for pest resistance, disease tolerance, and yield enhancement. RNAi-based pesticides offer environmentally friendly alternatives to chemical treatments.

  • Pest resistance engineering
  • Disease tolerance improvement
  • Yield trait optimization
  • RNAi-based biopesticides
Eco-friendly
Agricultural solutions
Testimonials

What Our Clients Say

Trusted by researchers worldwide for quality and reliability.

"The siRNA quality was exceptional. We achieved over 85% knockdown with minimal off-target effects. The GalNAc delivery worked perfectly for our liver target. Highly recommend their services."

AC
Dr. Amy Chen
Director, RNA Therapeutics Inc

"Excellent support for our shRNA library project. The team helped us design optimal hairpin sequences and provided high-quality plasmids. The stable cell lines are performing beautifully."

JM
Prof. James Miller
Principal Investigator, UCSF

"We've partnered with CD Biosynsis for multiple RNAi projects. The consistency in quality, from research grade to GMP, has been critical for our therapeutic development pipeline."

SL
Dr. Sarah Lee
VP Research, GeneSilence Bio
Literature Support

Scientific Foundation

Our platform is backed by peer-reviewed research.

Study 1

Potent and Specific Genetic Interference by Double-Stranded RNA

Discovery of RNAi mechanism in C. elegans, awarded the 2006 Nobel Prize.

Nature, 1998 - Fire & Mello
Study 2

GalNAc-siRNA Conjugates for Delivery of RNAi Therapeutics

Development of GalNAc delivery technology enabling clinical success of RNAi drugs.

Nature Reviews Drug Discovery, 2018
FAQ

Frequently Asked Questions

Find answers to common questions about our service.

Which RNAi format should I choose?
Choose siRNA for short-term knockdown (3-7 days) and rapid results. Choose shRNA for stable, long-term gene silencing in cell lines or in vivo. Choose miRNA mimics or inhibitors for modulating endogenous miRNA activity. Our team can help you select the optimal format based on your experimental goals.
What is the typical gene silencing efficiency?
With proper design, siRNA typically achieves 70-90% knockdown at the mRNA level. shRNA can achieve similar efficiency with stable expression. Efficiency depends on target accessibility, delivery method, and cell type. Our design service optimizes sequences for maximum knockdown.
What delivery system should I use?
GalNAc-siRNA conjugates are recommended for liver targets, providing >80% silencing with subcutaneous administration. LNPs enable broad tissue distribution for systemic delivery. C16 conjugates are designed for CNS delivery. Viral vectors are ideal for shRNA delivery for stable expression.
What quality control is included?
Every project includes comprehensive QC: mass spectrometry for identity confirmation, HPLC for purity analysis, potency assays for functional verification, and endotoxin testing for safety. GMP-grade products include additional validation and documentation.
What is the typical turnaround time?
Turnaround time ranges from 2-8 weeks depending on project complexity. Standard siRNA synthesis typically takes 2-3 weeks. shRNA cloning and validation may take 4-6 weeks. GMP-grade manufacturing requires 6-8 weeks. Expedited services are available upon request.
Do you provide design consultation?
Yes, expert design consultation is included with every project. Our team will help you select target sequences, design optimal RNAi molecules, choose appropriate chemical modifications, and recommend the best delivery strategy for your specific application.

Ready to Start Your RNAi Project?

Get in touch with our team to discuss your requirements and receive a customized quote.

Contact Us

Ready to Start Your Project?

Get a customized quote for your RNA Editing Services project. Our experts will respond within 24 hours.

No obligation
24h response
Expert consultation

Recommended Services

· Yeast Genome Editing Services
· Homology-Directed Repair (HDR) Services
· Microbial Genetic Engineering service
· Gene Knock-in Services
· Gene knockout/knockdown Services
· Zinc Finger Nuclease genome editing services

Related Resources

· Cost and Efficiency Analysis of CRlSPR-Cas9 Knockout Services in Mice and Cell Lines
· Validating CRISPR Knockouts: Best Practices for qPCR, Sequencing, and Functional Assays
· Step-by-Step Guide to Generating CRISPR Knockout Cell Lines for Research
Quick Links

Home

Products

Services

About Us

Contact Us

Follow Us
CONTACT US

USA

Tel:

Email:

Japan

Tel:

Email:

Korea

Tel:

Email:

Copyright © 2026 CD Biosynsis. All rights reserved.