CD Biosynsis provides comprehensive genetic circuit engineering services for synthetic biology researchers around the world to facilitate their cutting-edge research. We provide tailored solutions and powerful tools to bring diverse synthetic applications and creative ideas to fruition.
Introduction to Genetic Circuit Engineering
Synthetic biology can be used to customize biomedicine and biotechnology applications by rewiring genetic networks of natural biological cells. It aims to engineer and redesign biological systems. Inspired by the design of electronic logic circuits, synthetic biology enables the synthesis of genetic logic circuits and cell reprogramming.
Genetic circuit engineering refers to the synthesis of unnatural DNA segments that encode RNA molecules or proteins to control each other’s levels. Distinguished from top-down genomic engineering, genetic circuit engineering is a bottom-up approach. The main purpose of genetic circuit engineering is to understand how natural systems are reconstructed in the laboratory. In recent years, genetic engineering has progressed that it is able to construct novel genetic circuits with different functions and activation mechanisms. The achievements in genetic circuit engineering are remarkable.
Figure 1. Engineered gene circuits. (Ausländer S & Fussenegger M., 2016)
Applications of Genetic Circuit
- Modification of cellular functions
- Metabolic engineering
- Tissue engineering
- Gene therapy
- Smart plants
- Creation of cellular responses
- Industrial fermentation
- Chemical production
- Microbiome therapeutic bacteria
- More possibilities
Service Offering
CD Biosynsis provides one-stop services of genetic circuit engineering to help our customers bring their innovative ideas to reality.
Genetic Circuit Design
Genetic circuits can perform logical functions mimicking those observed in electronic circuits and exhibit control over the flow of information in biological systems. With advanced computer-aided design and design automation technologies, we provide comprehensive services covering the design of input, operation and output modules, biological logic gates, and genetic oscillators.
Engineering of Gene Switches
As the basic component of genetic circuits, synthetic gene switches can intervene and control gene expression at different levels. We provide professional services for the engineering of both transcriptional and posttranscriptional gene switches.
Engineering of Logic Gates
Logic gates play an essential role in constructing genetic circuits to customize cell signaling in synthetic biology. Our scientists are capable of engineering modular and orthogonal genetic logic gates and building logic gates with digital-like switching behavior.
Engineering of Genetic Oscillators
Synthetic gene oscillators are important engineered regulatory motifs in genetic circuits. We can use cell-free systems to engineer genetic oscillators and characterize complex dynamic behaviors.
CD Biosynsis offers a variety of cutting-edge techniques to tailor genetic circuit engineering services for individual customer specifications. We are available for on-demand customer assistance via email or phone to help you with any problems or concerns you may have.
If you are interested in our services or have any specific needs, please feel free to contact us for more details.
References
- Ausländer S & Fussenegger M. Engineering gene circuits for mammalian cell–based applications. Cold Spring Harbor perspectives in biology, 2016, 8(7): a023895.
- Adamala K P, et al. Engineering genetic circuit interactions within and between synthetic minimal cells. Nature chemistry, 2017, 9(5): 431-439.
Home
