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Strain Engineering for Xanthan Gum

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CD Biosynsis is committed to improving the yield and shortening the production cycle of xanthan gum by selecting the best strains, optimizing fermentation media and fermentation conditions, and regulating the signaling molecules in the synthesis phase of xanthan gum.

Introduction of Synthetic Biology-Driven Xanthan Gum Production

Xanthan gum is an extracellular polysaccharide produced by Xanthomonas spp. and formed by the polymerization of repeating structural units. Xanthan gum has been widely used in more than 20 fields such as food, agriculture, and medicine due to its superior fluidity and stability. The synthetic pathway of xanthan gum has now been elucidated. However, the biosynthesis of xanthan gum is influenced by several factors, among which the strain issue, fermentation process, and post-treatment process greatly affect the quality of xanthan gum. Therefore, based on the synthetic biology platform, it is important to realize the modification and construction of high-yielding strains of xanthan gum to improve the ability of industrial fermentation to produce xanthan gum.

Uses of Xanthan Gum in various fields. (Besrour-Aouam N, et al., 2021)Figure 1. Uses of Xanthan Gum in various fields. (Besrour-Aouam N, et al., 2021)

What We Provide

Featured Services

  • We are able to regulate the expression of genes related to the processes of conversion of glucose to sugar phosphate, conversion of sugar phosphate to nucleotide diphosphate, and intracellular carbohydrate transport by means of genetic modification.
  • We are able to regulate the structural proteins of the gum gene cluster and promoter-regulated genes to regulate the synthesis of xanthan gum.
  • We are able to influence xanthan gum synthesis by controlling the synthesis and interpretation of cyclic di-guanosine acid.


  • Xanthan Gum.
  • Xanthan Gum -producing strains.

How We Can Help

Regulation of Xanthan Gum Biosynthesis

The process of producing xanthan gum using glucose as a substrate consists of three main stages, namely the synthesis of sugar-phosphate, the synthesis of ribulose diphosphate, a ribose precursor, and the synthetic assembly and secretion of xanthan gum pentasaccharide repeat units. Based on our understanding of the biosynthesis mechanism of xanthan gum, we provide regulation services for the different stages to help our customers improve the yield of xanthan gum. The specific services are as follows.

  • Gene regulation of the synthesis phase and assembly phase of xanthan gum precursors. We are able to use gene editing to regulate the relevant genes affecting xanthan gum biosynthesis at this stage. We have successfully improved the production of xanthan gum by regulating the genes encoding the following enzymes.
Gluconate phosphate dehydratase Glucose-6-phosphate dehydrogenase Glucose-6-phosphate isomerase UDP-glucose dehydrogenase
  • Regulatory signaling molecules. We are able to provide regulatory services involving di-guanosine signaling network systems and quorum sensing systems.

Optimization of Fermentation Conditions

The medium for the industrial production of xanthan gum generally contains trace elements as well as massive elements. Glucose and sucrose are the most commonly used carbon sources. We can help our customers to further optimize the fermentation system for xanthan gum production by determining the optimal production medium, temperature, pH, oxygenation, etc., based on the selected high-yielding strains of xanthan gum.

Applications of Xanthan Gum

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive xanthan gum production and meet the needs of customers in a variety of industries.

  • As a food thickening agent.
  • As a food additive.
  • Used in the manufacture of eye creams, face creams, etc.
  • As a component of the sugar coating in pharmaceuticals.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in xanthan gum production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.


  1. Riaz T, et al. A review of the enzymatic, physical, and chemical modification techniques of xanthan gum. Int J Biol Macromol. 2021 Sep 1; 186: 472-489.
  2. Kang Y, et al. Biosynthesis, structure and antioxidant activities of xanthan gum from Xanthomonas campestris with additional furfural. Carbohydr Polym. 2019 Jul 15; 216: 369-375.

Please note that all services are for research use only. Not intended for any clinical use.

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