CD Biosynsis provides customized synthetic biology solutions to help our customers overcome the challenges of traditional xylanase production to meet the growing demand for xylanases in a variety of fields including the paper industry, bakery industry, and pharmaceutical industry. We are committed to breaking the limitations faced by xylanases in large-scale production and industrial applications, developing super xylanases that can meet the properties required for extreme industrial production, and promoting the widespread use of xylanases in biotechnology and industrial production.
Advantages of Synthetic Biology-Driven Xylanases Production
Xylan is the second most abundant hemicellulosic polysaccharide in nature, accounting for about one-third of the renewable organic carbon source on earth. Xylanases are hydrolases that break down xylans with the help of other glycosidases and are produced by many microorganisms, including filamentous fungi, bacteria, yeasts and actinomycetes. Although fungal xylanases have the advantage of high activity, they face many limitations in large-scale production and industrial applications, which makes bacterial xylanases a strong contender in industry today. However, most currently available bacterial xylanases satisfy only a fraction of the properties required for practical industrial applications, which leaves industrial processes largely dependent on expensive and dangerous chemical processes. Recent advances in synthetic biology based on the availability of information on whole genome sequences and metabolic pathways have paved the way for the development of engineered xylanase producing microorganisms. It has made possible the design of super xylanases capable of meeting the required properties for extreme industrial production.
Figure 1. Strategies for designing super-xylanases with novel properties. (Chakdar H, et al., 2016)
What We Provide
CD Biosynsis' advanced synthetic biology platform and extensive expertise allows us to help our customers develop customized and effective strategies to achieve improved production of xylanases.
Featured Services
- Identification, cloning, and characterization of novel xylanase-encoding genes for enhanced xylanase expression.
- Screening and characterization of microbial strains capable of producing adequate yields of xylanases rather than producing undesired products.
- Overexpression of xylanase genes from different microorganisms such as extreme thermophilic bacteria in suitable hosts for the production of recombinant xylanases with high activity over a wide range of pH and temperature.
- Engineering of microbial xylanases toward different industrial applications.
Key Strategies and Technologies
Deliverables
- Xylanase-producing microorganisms.
- High-quality xylanase products, including bacterial xylanases and fungal xylanases.
How We Can Help
CD Biosynsis brings our professional knowledge and extensive experience in synthetic biology to help our customers produce xylanases with desired properties to better meet the needs of industrial and biotech applications. Our scientists can add useful features to xylanases for different application scenarios to design engineered xylanases with optimal performance.
Development of Synthetic Biology Chassis for Xylanase Production
Our advanced technologies and specialized solutions in bacterial synthetic biology and fungal synthetic biology can provide greater flexibility in the design and expression of engineered xylanases, allowing different types of microorganisms to acquire desirable properties and becoming the ideal chassis for the production of xylanases suitable for different application scenarios. We are committed to creating fully functional xylanases with high stability in extreme environments through synthetic biology to alleviate the reliance on expensive and dangerous chemical processes in current industrial processes. The following are the xylanases-producing bacteria and fungi with the potential to be developed as synthetic biology chassis. If you are interested in other microbial strains, please fill out the online inquiry form and tell us more about your project.
|
Actinomadura |
Anoxybacillus favithermus |
Arthrobacter sp. |
Aspergillus niger |
Aspergillus terreus |
| Bacillus amyloliquefaciens |
Bacillus circulans |
Bacillus halodurans |
Bacillus pumilus |
Bacillus stearothermophilus |
| Bacillus subtilis |
Clostridium thermocellum |
Flavobacterium frigidarium |
Geobacillus thermoleovorans |
Rhodothermus marinus |
| Sorangium cellulosum So9733-1 |
Stenotrophomonas maltophila |
Streptomyces thermovulgaris |
Thermotoga thermarum |
Trichoderma viride |
Xylanases Improvement Strategies Based on Synthetic Biology
- Low production efficiency and yield
We can help develop cell-free synthetic biology methods to enhance the expression of xylanases for improved productivity and yield.
- Low functionality
We can modify xylanases can use synthetic biology-based genetic tools and metabolic engineering strategies to create fully functional xylanases for biotechnological and industrial applications.
- Low stability
We can use synthetic biology techniques to engineer xylanases through mutagenesis and cloning to improve its stability.
Applications of Xylanase
CD Biosynsis provides customized solutions for synthetic biology-driven xylanase production to meet a wide range of applications in biotechnological and industrial production.
Application of xylanase in the paper and pulp industry
- Use of xylanase to bleach wood pulp to improve brightness and whiteness.
Application of xylanase in the bakery industry
- Use of xylanase to solubilize arabinoxylans and decrease the dough firmness.
Application of xylanase in biofuel production
- Use of xylanase to convert abundant lignocellulosic plant biomass into biofuels presents.
Want to Learn More?
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for industrial enzyme production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.
References
- Chakdar H, et al. Bacterial xylanases: biology to biotechnology. 3 Biotech. 2016, 6(2): 150.
- Shukla P. Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications. Indian J Microbiol. 2019, 59(4): 401-409.
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