CD Biosynsis has built an advanced synthetic biology platform with core expertise in metabolic engineering and cell factory engineering to help our customers achieve efficient production of propanol. Our multidisciplinary scientific team has the ability to provide our customers with effective synthetic biology approaches to help them increase their production capacity for n-propanol and isopropanol.
Advantages of Synthetic Biology-Driven Propanol Production
Propanol with the molecular formula C3H8O is an industrially attractive value-added chemical ideal for a wide range of applications. Although microbial production of both n-propanol and isopropanol from renewable resources can solve many problems inherent in chemical synthesis, the yield and productivity of microbial propanol production processes do not appear to be sufficient to compete with chemical production. Synthetic biology provides astounding abilities to develop biosynthetic pathways to improve propanol productivity, as well as to develop microbial chassis with high propanol tolerance or the ability to efficiently utilize low-cost feedstocks. These contribute significantly to overcome the challenges in microbial production of propanol and are expected to drive the global market for propanol.
Figure 1. Scheme of the engineered metabolic pathway for the production of 1,2-propanediol and 1-propanol in C. glutamicum. (Siebert D, Wendisch VF, 2015)
What We Provide
Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of propanol.
Featured Services
- Manipulating the metabolic fluxes toward the synthesis of propanol by heterologous gene expression.
- Metabolic engineering of the synthetic threonine pathway, the synthetic citramalate pathway, the synthetic succinate pathway, the synthetic 1,2-propanediol pathway, or the 2-ketobutyrate biosynthetic pathway to improve propanol production.
- Deletion of the endogenous genes that involved in competing pathways to reduce unwanted by-products and increase the propanol yield.
Key Strategies and Technologies
Deliverables
- Propanol-producing microorganisms.
- High-quality n-propanol (1-propanol) and isopropanol (2-propanol).
How We Can Help
CD Biosynsis provides our synthetic biology expertise and a set of advanced technologies to help our customers achieve high-yield production of propanol in bacteria and yeast. We have the ability to help our customers solve problems they may encounter in the microbial production of propanol.
Engineering of Microbial Chassis for Propanol Production
We are able to help our customers select the appropriate microbial strains from a large set of microorganisms including natural propanol-producing strains and engineered microbial strains, and leverage their inherent properties to develop synthetic biology chassis. If the strain you are interested in is not listed below, please fill out the online inquiry form and tell us more about your project.
| Propionibacterium acidipropionici |
Propionibacterium freudenreichii |
Propionibacterium shermanii |
Clostridium neopropionicum |
Clostridium beijerinckii |
| Clostridium acetobutylicum |
Clostridium autoethanogenum |
Corynebacterium glutamicum |
Thermobifida fusca |
Bacillus subtilis |
| Escherichia coli |
Lactobacillus panis |
Synechococcus elongatus |
Saccharomyces cerevisiae |
Kluyveromyces marxianus |
Metabolic Pathway Engineering for Propanol Production
Our scientists with extensive experience in metabolic engineering can help design and optimize biosynthetic propanol-producing pathways with improved yields and productivity in different microbial strains. We can develop synthetic biology strategies to redesign natural propanol-producing pathways or construct new synthetic pathways to enable the high-yield production of propanol from renewable resources.
Construction of Microbial Cell Factories for Industrial Production of Propanol
We are capable of providing our customers with a full range of services, from the selection of starting strains, pathway design, engineering and optimization, development of microbial cell factories, to the optimization of fermentation conditions to help them achieve industrial production of propanol. We can also partner with our customers to construct cell factories that can efficiently utilize inexpensive and renewable feedstocks such as xylose and CO2.
Applications of Propanol
CD Biosynsis is committed to harnessing the power of synthetic biology to fulfill the increasing demand for propanol in a variety of industries such as chemical industries, pharmaceuticals, cosmetics, coatings, and printing.
- Used as a solvent in the manufacturing of many products, such as cosmetics, perfumes, flavors, personal care products, polishes, cleaning products, coatings, printing inks, pigments, paint additives, dye solutions, lacquers, antifreeze, natural gums, and air care products.
- Used as a chemical intermediate to produce chemicals such as halides, esters, propyl amines, polypropylene, and propyl acetate.
- Used as an antiseptic, a disinfectant, and a sanitizing agent in the pharmaceutical industry.
- Used as biofuel in engines.
Want to Learn More?
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.
References
- Walther T, François J M. Microbial production of propanol. Biotechnology advances, 2016, 34(5): 984-996.
- Siebert D, Wendisch VF. Metabolic pathway engineering for production of 1, 2-propanediol and 1-propanol by Corynebacterium glutamicum. Biotechnology for biofuels, 2015, 8(1): 1-13.
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