Synthetic Biology
Strain Engineering for Polyethylene Terephthalate Biodegradation

Strain Engineering for Polyethylene Terephthalate Biodegradation

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Strain Engineering for Polyethylene Terephthalate Biodegradation

CD Biosynsis is able to design engineering bacteria based on the chemical structure of polyethylene terephthalate and use microorganisms to degrade waste plastics in the environment into monomers.

Advantages of Synthetic Biology-Driven Polyethylene Terephthalate Degradation

Polyethylene terephthalate is the most dominant variety of thermoplastic polyester and can be divided into fiber-grade polyester chips and non-fiber-grade polyester chips. Fiber polyester chips are used to manufacture polyester staple fiber and polyester filament, which are the most produced varieties of chemical fiber. Non-fiber polyester is widely used in the packaging industry, electronic appliances, medical and health care, construction, automotive, and other neighborhoods. Polyethylene terephthalate is very difficult to degrade in nature and has become one of the main sources of white pollution. The degradation of polyethylene terephthalate is not only involved in environmental microbiology, but also synthetic biology. Polyethylene terephthalate is one of the commonly used plastics, and its traditional recycling methods are mechanical recycling, landfill, incineration, and chemical hydrolysis, which have disadvantages such as waste of land resources, high energy consumption, and generation of harmful substances. However, the degradation of polyethylene terephthalate using synthetic biology methods is less energy-consuming and environmentally friendly.

System for the identification and functional testing of candidate PET hydrolase enzymes. (Carr CM, et al., 2020)Figure 1. System for the identification and functional testing of candidate PET hydrolase enzymes. (Carr CM, et al., 2020)

What We Provide

Featured Services

  • We are able to improve the biodegradability of polyethylene terephthalate hydrolase through overall stiffness improvement, flexibility tuning of key regions, and protein surface electrostatic charge optimization.
  • We are able to help our customers identify additional polyethylene terephthalate hydrolases through database searches.


  • Polyethylene terephthalate hydrolase.
  • Xanthan Gum -producing strains.

How We Can Help

Design of Efficient Polyethylene Terephthalate Hydrolase

With the continued growth of large-scale sequencing data, various polyethylene terephthalate hydrolases have been identified and characterized. We are able to assist polyethylene terephthalate hydrolase design through machine learning and ancestral sequence reconstruction to help our customers achieve high-throughput screening and molecular modification of polyethylene terephthalate hydrolase.

Construction of a Whole-Cell Catalytic System for Polyethylene Terephthalate Degradation

Polyethylene terephthalate hydrolase is a novel bacterial-derived polyethylene terephthalate degrading enzyme that can decompose high crystallinity PET at room temperature. We are able to construct an engineered whole-cell biocatalyst that mimics both the adsorption and degradation steps in the hydrolysis of polyethylene terephthalate hydrolase substrates to achieve efficient degradation of high crystallinity polyethylene terephthalate.

Applications of Polyethylene Terephthalate

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive polyethylene terephthalate production and meet the needs of customers in a variety of industries.

  • Used in the manufacture of baby bottles.
  • Used in the manufacture of toys.
  • Used in the manufacture of automobiles.
  • Application in the field of electronic appliances.
  • Made into films for use as substrates for audio, video, motion picture films, etc.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in polyethylene terephthalate production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.


  1. Carr CM, et al. Microbial Polyethylene Terephthalate Hydrolases: Current and Future Perspectives. Front Microbiol. 2020 Nov 11; 11: 571265.
Please note that all services are for research use only. Not intended for any clinical use.

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