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Trusted by Leading Research & Pharma Institutions

MicroRNA Agomir/Antagomir Synthesis Services

Accelerate your miRNA research with custom agomir and antagomir synthesis consistently manufactured to your exact specifications. From functional studies to in vivo experiments, we deliver high-quality, chemically modified miRNA tools with industry-leading purity and stability.

HPLC Purified
MS Verified
In Vivo Ready
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Trusted by leading research and pharmaceutical institutions

Harvard
Pfizer
MIT
Roche
Stanford
Novartis

Why Choose Us

Chemical modifications for enhanced stability
Effect lasts up to 5-6 weeks in vivo
MS verification on every product
Covers human, mouse, rat miRNAs

Agomir Synthesis

Double-stranded miRNA agonists with enhanced delivery

Antagomir Synthesis

Single-stranded miRNA inhibitors for loss-of-function

In Vivo Grade

Cholesterol conjugation and endotoxin testing

Effect Duration
5-6 Weeks
Overview Technology Specifications Workflow Applications FAQ
Service Overview

Comprehensive MicroRNA Agomir/Antagomir Solutions

Our platform combines advanced chemical synthesis with proprietary modification technologies to deliver miRNA tools with superior stability and efficacy.

MicroRNA Agomir

Chemically modified double-stranded small RNA that mimics endogenous miRNA function. Agomir offers higher cell membrane affinity, enhanced stability, and longer-lasting effects compared to standard miRNA mimics, making it ideal for in vivo functional studies.

  • Enhanced cellular uptake and delivery
  • Resistance to nuclease degradation
  • Effect duration: up to 5-6 weeks in vivo
  • Multiple administration routes supported

MicroRNA Antagomir

Single-stranded antisense oligonucleotide designed to specifically bind and inhibit endogenous miRNA activity. Antagomir enables precise loss-of-function studies with enhanced stability for sustained inhibition effects.

  • High specificity for target miRNA
  • LNA and 2'-OMe modifications available
  • Effective for in vivo applications
  • Multiple targeting strategies supported

Complete Coverage

All human, mouse, and rat miRNAs from miRBase database with custom synthesis available.

Quality Verified

Every product undergoes mass spectrometry and HPLC analysis for guaranteed purity.

Flexible Options

From standard research grade to in vivo grade with cholesterol conjugation.

Ready to Advance Your miRNA Research?

Get a customized quote for your agomir/antagomir project.

Technology Platform

Advanced Synthesis Technologies

Industry-leading synthesis platforms ensuring high-quality output for every project.

Chemical Modifications

Advanced chemical modifications including 2'-O-methyl, 2'-fluoro, phosphorothioate backbone, and LNA to enhance stability and efficacy.

2'-OMe 2'-F PTO LNA

Quality Verification

Every product undergoes mass spectrometry analysis and HPLC purification to ensure sequence accuracy and high purity.

ESI-MS HPLC LC-MS

In Vivo Delivery

Cholesterol conjugation and other targeting modifications for enhanced in vivo delivery and tissue-specific uptake.

Cholesterol GalNAc Endotoxin

Quality Control

MS Mass spectrometry verification
HPLC High purity ≥90% guaranteed
PAGE Ultra-high purity optional
COA Certificate of Analysis included

Purification Options

HPLC Standard purification ≥90%
PAGE Ultra-high purity ≥95%
RP-HPLC Reverse phase for duplexes
IEC Ion exchange chromatography
Specifications

Flexible Options for Diverse Needs

Comprehensive specifications to meet your research requirements.

Parameter miRNA Agomir miRNA Antagomir In Vivo Grade
Length 21-23 nt (double-stranded) 21-23 nt (single-stranded) Custom
Purity ≥90% by HPLC ≥90% by HPLC ≥95% by PAGE
Modifications 2'-OMe, Cholesterol 2'-OMe, LNA, PTO Cholesterol, Endotoxin Free
Scale Range 5-250 nmol 5-250 nmol Custom
Species Coverage Human, Mouse, Rat Human, Mouse, Rat Custom
Application In vitro & In vivo In vitro & In vivo Animal Studies
Workflow

Streamlined Process from Design to Delivery

Our proven 5-step workflow ensures quality and efficiency at every stage.

1

Consultation

Sequence validation and modification strategy

2

Design

Optimization and chemical modification placement

3

Synthesis

Solid-phase synthesis with real-time monitoring

4

QC

MS and HPLC verification

5

Delivery

Secure packaging with comprehensive report

Applications

Diverse Applications Across Research

Our synthesis services support research and development in multiple fields.

Oncology Research

miRNA agomir and antagomir are powerful tools for studying gene regulation in cancer biology. Restore tumor suppressor miRNAs or inhibit oncogenic miRNAs to understand disease mechanisms and validate therapeutic targets.

  • Tumor suppressor miRNA restoration
  • Oncogenic miRNA inhibition
  • Drug target validation
  • Combination therapy studies
500+
Validated miRNA targets

Cardiovascular Research

MicroRNAs play crucial roles in cardiovascular physiology and pathology. Use agomir/antagomir to study heart development, vascular function, and disease mechanisms in atherosclerosis, myocardial infarction, and cardiac hypertrophy.

  • Cardiac hypertrophy studies
  • Atherosclerosis research
  • Vascular function modulation
  • Heart failure mechanisms
1/3
Human genes regulated by miRNAs

Neuroscience Research

MicroRNAs are essential regulators of neuronal development, synaptic plasticity, and neuroprotection. Investigate neurological disorders and develop therapeutic strategies using targeted miRNA modulation.

  • Neurodegeneration studies
  • Synaptic plasticity research
  • Neuroprotection mechanisms
  • CNS drug development
70%
Neuronal miRNA expression
Testimonials

What Our Clients Say

Trusted by researchers worldwide for quality and reliability.

"The agomir products exceeded our expectations. The stability in vivo was remarkable, lasting throughout our 4-week study period. Highly recommended for any miRNA functional research!"

S
Senior Scientist
Biotechnology Company

"Excellent quality and fast delivery. The technical support team helped us optimize our transfection protocol. Will definitely use again for our cardiac research projects."

P
Research Director
Academic Research Institution

"We've been using their antagomir service for our cancer research for over two years. Consistent quality, reproducible results, and great customer service every time."

L
Lead Researcher
Pharmaceutical Company
Scientific Literature

Scientific Foundation

Our platform is backed by peer-reviewed research.

52 Citations

Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases

Saenz-Pipaon G, Dichek DA. Atherosclerosis. 2023.

Comprehensive review of antagomir chemistry and targeted delivery approaches for cardiovascular disease treatment.

View DOI
45 Citations

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Multiple authors. Frontiers in Bioengineering and Biotechnology. 2023.

Review of nanotechnology-based miRNA drug delivery systems for cancer therapeutics.

View DOI
35 Citations

MiRNA-Based Therapies for the Treatment of Inflammatory Bowel Disease

Multiple authors. Inflammatory Bowel Diseases. 2023.

Comprehensive review of agomir and antagomir applications in inflammatory disease research.

View DOI
28 Citations

miRNA as Drug: Antagomir and Beyond

Cannataro R, Cione E. Current Pharmaceutical Design. 2023.

Commentary on miRNA as therapeutic agents including antagomir and agomir approaches.

View DOI
18 Citations

Chemical modification patterns for microRNA therapeutic mimics

Multiple authors. Nucleic Acids Research. 2024.

Structure-activity relationship study on miR-200c mimics with various chemical modifications.

View DOI
FAQ

Frequently Asked Questions

Find answers to common questions about our service.

Agomir is a chemically enhanced version of miRNA mimic with superior properties for in vivo applications. Compared to standard mimics, agomir has higher affinity for cell membranes, enhanced nuclease resistance, and longer-lasting effects (up to 5-6 weeks in vivo vs. days for standard mimics). Agomir is specifically designed for animal experiments including injection, inhalation, and feeding administration.
We offer comprehensive modification options including: 2'-O-methyl (2'-OMe) for enhanced stability, 2'-fluoro (2'-F) for RNase resistance, phosphorothioate (PTO) backbone modifications, locked nucleic acid (LNA) for increased affinity, and cholesterol conjugation for improved in vivo delivery. Our team can help design the optimal modification strategy for your specific application.
Our standard service covers all human, mouse, and rat miRNAs listed in the miRBase database. Custom synthesis for other species is also available upon request. Each miRNA sequence is validated against authoritative databases to ensure accuracy.
In Vivo Grade products are synthesized at larger scales with enhanced purification (PAGE ≥95%), endotoxin testing to meet safety standards for animal dosing, and optional cholesterol conjugation for improved tissue-specific delivery. These products are specifically designed and validated for preclinical animal studies.
Every product undergoes rigorous quality control including mass spectrometry (ESI-MS) for exact molecular weight confirmation and HPLC or PAGE analysis for purity assessment. We guarantee ≥90% purity for standard products and ≥95% for in vivo grade. Full Certificates of Analysis are included with each shipment.
Agomir and Antagomir support multiple administration routes including intravenous injection, subcutaneous injection, intraperitoneal injection, intratracheal inhalation, and oral administration. The optimal route depends on your specific research objectives and target tissue. Our technical team can provide detailed protocols and recommendations.

Ready to Start Your Project?

Get a customized quote for your MicroRNA Agomir/Antagomir Synthesis project. Our experts will respond within 24 hours.

No obligation
24h response
Expert consultation

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