CD Biosynsis is dedicated to using powerful synthetic biology techniques to create synthetic enzymes, design synthetic metabolic pathways, and engineer cell factories to provide innovative approaches for ethanol production. We offer our expertise and synthetic biology platform to help our customers discover new path to produce ethanol in a sustainable, environmentally friendly, and efficient way.
Advantages of Synthetic Biology-Driven Ethanol Production
Ethanol with the molecular formula C2H6O is an important industrial chemical. Traditionally, ethanol is produced by fermentation using food crops (e.g., corn, sugar cane, and sorghum) as feedstocks. However, concerns about the food crisis and global warming have promoted researchers to keep exploring ways to make ethanol from non-edible biomass resources such as corncobs, corn stover, wheat straw, wood chips and even waste and garbage. The emergence of synthetic biology has the potential to revolutionize ethanol production. Rapid advances in synthetic biology approaches have accelerated process improvements to improve the yield and quality of ethanol production, reduce the cost of feedstock, improve ethanol productivity, and drive the process to be eco-friendly.
Figure 1. Frequency of synthetic biology patents related to cellulosic ethanol. Source: Research data from Questel-orbit platform. (Fantinel A L, et al., 2021)
What We Provide
Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of ethanol.
Featured Services
- Development of genetically modified organisms to solve ethanol production problems.
- Establishment of new metabolic pathways to broaden substrate range.
- Deletion of competing pathways to reduce byproducts.
- Design and engineering of enzymes to improve pH stability, thermostability, and specific activity for efficient conversion of different substrate into ethanol.
Key Strategies and Technologies
Deliverables
- Ethanol-producing microorganisms.
- High-quality ethanol products.
How We Can Help
CD Biosynsis leverages our expertise in bacterial synthetic biology, yeast synthetic biology, and algae synthetic biology to help our customers overcome challenges of ethanol production and provide plenty of promising methods and technical tools to improve ethanol production. Our dedicated scientists can develop synthetic biology strategies to meet the specific needs of our customers for ethanol production.
Development of Synthetic Biology Chassis for Ethanol Production
Our scientists have been working to explore the potential of different bacterial, yeast, and algal strains as synthetic biology chassis for ethanol production. We can develop synthetic biology tools and approaches to improve ethanol productivity, thermotolerance, ethanol tolerance, and substrate utilization of these chassis. The following are synthetic biology chassis that have been successfully or are under development for ethanol biosynthesis. We can help select suitable host strains for follow-up studies according to customer needs.
| Escherichia coli |
Klebsiella oxytoca |
Zymomonas mobilis |
Lactobacillus fermentum |
| Weissella confusa |
Clostridium thermocellum |
Clostridium thermohydrosulfuricum |
Erwina chrysanthemi |
| Synechococcus sp. |
Saccharomyces cerevisiae |
Kluyveromyces marxianus |
Zygosaccharomyces bailii |
| Dekkera bruxellensis |
Ogataea polymorpha |
Hansenula polymorpha |
Kluyveromyces lactis |
| Pichia pastoris |
Yarrowia lipolytica |
Zygosacchharomyces rouxii |
Kluyveromyces fagilis |
| Schizosaccharomyces pombe |
Chlamydomonas reinhardtii |
Cyanidioschyzon merolae |
Chlorella sorokiniana |
Sustainable Feedstocks for Ethanol Production
We are committed to developing synthetic biology strategies to achieve sustainable ethanol production from cellulose biomass and algal biomass, including but not limited to agricultural residues, forestry residues, municipal solid waste, industrial wastes, and algal polysaccharides. We have experience in the engineering and modification of synthetic biology chassis and in the construction of cell factories for efficient ethanol production from different feedstocks.
Development of Cell-Free Enzyme System for Ethanol Production
Our scientists have also been working on the development of cell-free enzyme system to establish more efficient ethanol production system than conventional fermentation. We have expertise in the design of cell-free enzymatic reaction cascades and the development of yeast cell-free enzyme systems. We look forward to partnering with our customers to explore efficient conversion of glucose to ethanol in a cell-free system.
Applications of Ethanol
CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive ethanol production and meet the needs of customers in a variety of industries.
- Used as an engine fuel and fuel additive.
- Used as a solvent in the synthesis of organic chemicals.
- Used in the manufacture of varnishes, perfumes, and paints.
- Used as a common ingredient in cosmetics, personal care, and beauty products.
- Used as a preservative for biological specimens.
- Used as a food additive in the preparation of essences and flavorings.
- Used as a common ingredient in hand sanitizers and household cleaning products.
- Used as a solvent, excipient, or preservative in the manufacture of medicines.
Want to Learn More?
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.
References
- Fantinel A L, et al. Technological Advances in Synthetic Biology for Cellulosic Ethanol Production. Biorefineries-Selected Processes, 2021.
- Liu C G, et al. Cellulosic ethanol production: progress, challenges and strategies for solutions. Biotechnology advances, 2019, 37(3): 491-504.
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