CD Biosynsis provides high-quality and customized metabolic pathway synthesis and optimization services to facilitate the cutting-edge research of synthetic biology researchers around the world.
Introduction to Metabolic Pathway Synthesis and Optimization
Metabolic engineering initially focused on the directed modification of metabolic pathways for microbial synthesis of various products. It mainly deals with the design, construction, and optimization of synthetic routes of both natural and non-natural products. Synthetic biology focuses on the design and construction of novel biological components. The assembly of these parts helps to create synthetic biological pathways. Synthetic biological components, devices and modules provide great support for metabolic pathway engineering, eventually led to the overlapping of synthetic biology and metabolic engineering.
Since the emergence of synthetic biology, metabolic engineering combined with synthetic biology has become one of the most promising fields. Synthetic biology can provide metabolic engineering with information and biological component about different biological phenomena, which can be used by metabolic engineering to optimize the biological synthesis trajectories of desired compounds. Metabolic pathway synthesis and optimization, along with the necessary assembly techniques, play fundamental roles in microbiology, biochemistry, and many other related fields. Metabolic engineering and synthetic biology have made great progress in biotechnology, and have made great contributions to solving problems in the production of drugs, vaccines, and compounds. In addition, these areas have also increased our understanding of biological functions.
Figure 1. Different stages for the development of synthetic biology and metabolic engineering projects. (García-Granados R, et al., 2019)
Service Offering
CD Biosynsis provides comprehensive metabolic pathway synthesis and optimization services, including but not limited to:
Metabolic Pathway Synthesis
Metabolic pathway synthesis involves the assembly of intricate metabolic pathways and genetic circuits to optimize the production yields of metabolites in natural systems or create novel biological systems that can produce exogenous metabolites. CD Biosynsis provides one-stop metabolic pathway synthesis services from metabolic pathway design, construction and transformation of pathway modules, to metabolite analysis and validation.
Metabolic Pathway Optimization
Improving the function of metabolic pathways usually requires several rounds of the design-build-test cycle to optimize each and single part of the gene circuit. CD Biosynsis provides both combinatorial and sequential optimization strategies for metabolic pathway engineering to help customers get optimal metabolic pathways.
De Novo Metabolic Pathway Reconstruction
Due to the lack of experimentally identified enzymes and metabolites, many reactions are still missing even in known pathways. De novo metabolic pathway reconstruction for the prediction of reactions based on the chemical structures of metabolites plays an important role in the elucidation of previously unknown reactions. CD Biosynsis provides advanced de novo metabolic pathway reconstruction strategies for gap filling in metabolic networks.
CD Biosynsis is fully committed to providing our customers with tailored one-stop solutions to help them overcome the challenges in synthetic biology. Our scientists have the ability to bring diverse creative ideas to fruition. If you are interested in our services, please contact us for more details.
References
- García-Granados R, et al. Metabolic engineering and synthetic biology: synergies, future, and challenges. Frontiers in bioengineering and biotechnology, 2019, 7: 36.
- Stephanopoulos G. Synthetic biology and metabolic engineering. ACS synthetic biology, 2012, 1(11): 514-525.
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