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Protein library design

CD Biosynsis's synthetic biology platform is dedicated to providing high-quality protein library design services to help biologists around the world design protein variant collections to support innovation in a variety of fields.

Introduction to Engineering Metabolic Pathways for Chemical Production

Protein library design in synthetic biology involves creating diverse collections of protein variants, with the primary aim of fine-tuning their functionalities to cater to specific applications. Proteins, being essential molecules, exhibit a vast array of roles within organisms, thus prompting synthetic biologists to exploit this diversity to engineer novel proteins imbued with designated properties. These properties encompass improved catalytic activity, enhanced binding specificity, altered substrate specificity, increased stability, and many others. To create and screen large numbers of protein variants to identify those with the desired characteristics, protein libraries are often designed according to rational design principles, directed evolution, and computational methods.

Protein library design plays a crucial role in facilitating the emergence of innovative biotechnological advancements. Within the sphere of synthetic biology, proteins can be engineered to perform specific functions such as enzymes for industrial processes, therapeutic proteins for medical applications, biosensors for measuring molecules of interest, etc. It is believed that the significance of protein library design lies in its ability to harness the versatility of proteins for diverse purposes, opening up new avenues for innovation and problem-solving within an array of disciplines.

Fig 1. Unbiased libraries in protein directed evolution.Fig 1. Unbiased libraries in protein directed evolution. (Sayous, V, et al., 2020)

Service Offering

Our services include but not limited to the following:

Custom Protein Engineering

Create protein libraries tailored to specific client needs, targeting properties such as enzyme activity, binding affinity, and stability.

Functional Optimization

Improve the performance of existing proteins for industrial processes, medical treatments, or other applications.

Biosensor Development

Design proteins that bind to specific molecules, enabling the development of biosensors for the detecting of contaminants, pathogens, or biomarkers.

Enzyme Engineering

Engineer enzymes with enhanced catalytic activity or specificity for biocatalysis and green chemistry.

Therapeutic Protein Design

Development of novel therapeutic proteins with improved efficacy, reduced side effects, and enhanced delivery characteristics.

Why Choose Us?

Fig 2. Expertise.

Expertise. The team on our platform has expertise in protein engineering, synthetic biology and related fields to ensure high quality results.

Fig 2. Expertise.

Technological Infrastructure. Access to cutting-edge tools and methodologies for designing, creating, and analyzing protein libraries.

Fig 2. Expertise.

Speed and Efficiency. Rapid screening of large protein libraries using high-throughput technology to speed up the optimization process.

Fig 2. Expertise.

Interdisciplinary Approach. Combining knowledge from biology, chemistry, engineering, and computer science to tackle complex protein design challenges.

CD Biosynsis offers a wide range of cutting-edge technologies and has an experienced scientific team of biologists, bioinformaticians, and chemists dedicated to helping synthetic biology researchers around the world solve any challenges they encounter in their projects. If you have any specific needs, please feel free to contact us for more details.


  1. Sayous, V.; et al. Unbiased libraries in protein directed evolution. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2020, 1868(2): 140321.

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