Gene: CLTRN
Official Full Name: collectrin, amino acid transport regulatorprovided by HGNC
Gene Summary: This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18659 | CLTRN Knockout cell line (HEK293) | Human | CLTRN | 1:3~1:6 | Negative | Online Inquiry |
KO18660 | CLTRN Knockout cell line (A549) | Human | CLTRN | 1:3~1:4 | Negative | Online Inquiry |
CLTRN Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the CLTRN gene function through targeted gene disruption. By employing advanced CRISPR-Cas9 technology, these cell lines are designed to provide researchers with an invaluable tool to investigate the biological roles of CLTRN and its associated pathways, particularly in the context of cellular signaling, development, and disease mechanisms.
The primary function of the CLTRN Gene Knockout Cell Lines lies in their ability to decode the phenotypic and molecular consequences of abolishing CLTRN expression. By enabling the absence of this gene, researchers can observe changes in cellular behaviors, including proliferation, differentiation, and response to stimuli. This system operates on the principle of precision gene editing, ensuring a specific and effective knockout of the target gene, thereby preserving the integrity of adjacent genomic regions.
In scientific research, these cell lines hold significant promise for elucidating the pathological roles of CLTRN in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. In clinical settings, they can aid in the identification of new therapeutic targets and the development of gene-based treatments. Researchers can leverage these cell lines for drug screening, biomarker discovery, and functional validation of gene-related hypotheses.
What sets the CLTRN Gene Knockout Cell Lines apart from other commercially available models is their rigorously validated performance, which includes comprehensive genomic characterization and functional assays. These cell lines not only streamline experimental workflows but also enhance reproducibility and reliability in research findings.
For researchers and clinicians looking to advance their understanding of gene functions and disease mechanisms, CLTRN Gene Knockout Cell Lines represent a groundbreaking advancement. Their ability to provide insights into complex biological processes is crucial for driving innovations in therapeutic development.
At our company, we pride ourselves on our expertise in creating high-quality, genetically modified cell lines backed by robust scientific validation, ensuring that researchers have access to the best tools for advancing their understanding of gene function and its implications in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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