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Zbp1 Knockout Cell Lines

Gene: ZBP1

Official Full Name: Z-DNA binding protein 1provided by HGNC

Gene Summary: This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00223 Zbp1 gRNA3-gRNA4 KO plasmid Zbp1 $850

Background

ZBP1 Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology and genetics, specifically designed to facilitate research applications focused on the Z-DNA binding protein 1 (ZBP1). These genetically modified cell lines have undergone targeted gene editing to effectively eliminate the expression of the ZBP1 gene, allowing researchers to investigate its functional role and implications in various biological processes, including innate immune responses and cellular stress mechanisms.

The key function of ZBP1 is its involvement in the recognition of double-stranded RNA and the subsequent activation of signaling pathways that govern immune responses. By utilizing ZBP1 gene knockout cell lines, researchers can observe the cellular behavior in the absence of ZBP1, thereby elucidating its contributions to antiviral defense mechanisms and apoptosis. This targeted approach enables a deeper understanding of how disruptions in such pathways can contribute to disease states, particularly in viral infections, cancer, and autoimmune disorders.

From a scientific and clinical perspective, these cell lines are invaluable tools for both basic and applied research. They provide a robust model for testing therapeutic strategies aimed at modulating immune responses, and can significantly aid in the discovery of novel drug candidates targeting innate immune pathways. Furthermore, these cell lines can enhance the reproducibility of experimental results, offering researchers a consistent and reliable system for their studies.

A standout advantage of ZBP1 Gene Knockout Cell Lines is their specificity and efficiency, achieved through precise genome editing techniques such as CRISPR-Cas9. Compared to traditional methods of gene knockdown, these knockout cell lines offer complete ablation of the target gene, thereby ensuring more definitive conclusions regarding gene function. This strength positions them favorably against alternative models, which may exhibit variable expression levels.

For researchers and clinicians, the availability of ZBP1 Gene Knockout Cell Lines translates to enhanced experimental accuracy and accelerates the path from discovery to application, ultimately contributing to advances in therapeutic solutions. By integrating our expertise in genetic engineering with cutting-edge research techniques, our company is committed to providing high-quality biological products that empower the scientific community to explore and innovate in the ever-evolving landscape of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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