Gene: ZRANB1
Official Full Name: zinc finger RANBP2-type containing 1provided by HGNC
Gene Summary: Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. Is active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03955 | ZRANB1 Knockout cell line (HeLa) | Human | ZRANB1 | 1:3~1:6 | Negative | Online Inquiry |
KO03956 | ZRANB1 Knockout cell line (HCT 116) | Human | ZRANB1 | 1:2~1:4 | Negative | Online Inquiry |
KO03957 | ZRANB1 Knockout cell line (HEK293) | Human | ZRANB1 | 1:3~1:6 | Negative | Online Inquiry |
KO03958 | ZRANB1 Knockout cell line (A549) | Human | ZRANB1 | 1:3~1:4 | Negative | Online Inquiry |
ZRANB1 Gene Knockout Cell Lines are genetically modified cell lines in which the ZRANB1 gene has been selectively disrupted or knocked out. ZRANB1, coding for a zinc finger protein implicated in various cellular processes, plays a crucial role in DNA repair and gene regulation. By creating knockout models, researchers can investigate the functional consequences of ZRANB1 loss on cellular behavior, protein interactions, and gene expression profiles.
The primary mechanism of these knockout cell lines involves the use of CRISPR-Cas9 technology, which allows for precise editing of the genome to disable the ZRANB1 gene. This gene editing technology enables researchers to eliminate ZRANB1 functions, paving the way for in-depth studies into its roles in cellular processes such as proliferation, apoptosis, and response to DNA damaging agents. As such, ZRANB1 gene knockout cell lines are valuable tools for elucidating the gene's contribution to health and disease.
From a scientific viewpoint, ZRANB1 knockout cell lines have significant applications in both research and clinical settings. They allow investigators to model diseases associated with genomic instability, such as cancer, and to develop targeted therapies aimed at restoring normal cellular functions. Moreover, these cell lines facilitate high-throughput screening of compounds that may rescue the phenotypic defects observed in ZRANB1-deficient cells.
A standout feature of our ZRANB1 gene knockout cell lines is their superior reliability compared to other knockout models. They are rigorously validated and come with robust characterization data, ensuring reproducibility across multiple experiments. This reliability allows researchers to confidently draw conclusions based on their findings.
For researchers and clinicians, the value of ZRANB1 gene knockout cell lines lies in their ability to provide insights into critical biological pathways and disease mechanisms, ultimately accelerating the translation of basic research into clinical applications. With our continuous commitment to quality and innovation, our company specializes in providing advanced biological products that empower the scientific community to push the boundaries of knowledge and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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