Gene: ZNF703
Official Full Name: zinc finger protein 703provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription factor binding activity and metal ion binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of mammary gland epithelial cell proliferation; and regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nuclear matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26216 | ZNF703 Knockout cell line (HeLa) | Human | ZNF703 | 1:3~1:6 | Negative | Online Inquiry |
KO26217 | ZNF703 Knockout cell line (HCT 116) | Human | ZNF703 | 1:2~1:4 | Negative | Online Inquiry |
KO26218 | ZNF703 Knockout cell line (HEK293) | Human | ZNF703 | 1:3~1:6 | Negative | Online Inquiry |
KO26219 | ZNF703 Knockout cell line (A549) | Human | ZNF703 | 1:3~1:4 | Negative | Online Inquiry |
ZNF703 Gene Knockout Cell Lines are advanced cellular models utilized to study the biological functions of the ZNF703 gene, a critical regulator implicated in various oncogenic pathways. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to create a precise knockout of the ZNF703 gene. This knockout effectively removes the gene's expression, allowing researchers to observe the resultant phenotypic alterations and deduce the gene's role within cellular contexts.
The key mechanisms underlying these knockout cell lines involve the disruption of ZNF703's transcriptional regulatory functions. By eliminating expression, scientists can investigate the downstream effects on cell proliferation, differentiation, and apoptosis, providing insights into tumorigenesis, particularly in breast cancer, where ZNF703 serves as a significant marker for aggressive disease. The ability to analyze these changes in a controlled environment enhances understanding of the gene's contribution to cell signaling pathways, offering potential avenues for therapeutic intervention.
In research and clinical applications, ZNF703 Gene Knockout Cell Lines serve as a pivotal tool for elucidating the role of ZNF703 in cancer biology. They provide a unique platform for drug discovery and testing, especially for compounds targeting ZNF703-related signaling pathways. Compared to traditional cell lines that express ZNF703, these knockout models offer researchers a distinct advantage by providing a clearer picture of interactions without the confounding effects of the gene's expression.
Furthermore, ZNF703 Gene Knockout Cell Lines are indispensable for biomarker validation studies. Their ability to readily demonstrate the impact of ZNF703 loss on cellular behavior makes them highly valuable for developing precision medicine strategies aimed at individualizing treatment options for patients with ZNF703-associated malignancies.
Our company brings a wealth of expertise in genetic engineering and cell line development, ensuring that every product meets the highest standards of quality and accuracy. By choosing ZNF703 Gene Knockout Cell Lines, researchers and clinicians are equipped with a powerful tool to advance their understanding of cancer biology and contribute meaningfully to the future of therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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