Gene: ZNF554
Official Full Name: zinc finger protein 554provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30639 | ZNF554 Knockout cell line (HeLa) | Human | ZNF554 | 1:3~1:6 | Negative | Online Inquiry |
KO30640 | ZNF554 Knockout cell line (HCT 116) | Human | ZNF554 | 1:2~1:4 | Negative | Online Inquiry |
ZNF554 Gene Knockout Cell Lines represent a specialized and effective tool for investigating the biological roles of the ZNF554 gene across various cellular contexts. These cell lines are meticulously engineered to disrupt the ZNF554 gene through targeted CRISPR/Cas9 technology, leading to a complete knockout of its expression. The precise editing allows researchers to study the functional implications of ZNF554, a gene implicated in essential cellular processes, such as gene regulation, cellular differentiation, and response to stress.
The fundamental mechanism behind these knockout cell lines involves the introduction of a double-stranded break in the DNA at the ZNF554 locus, which is then repaired by the cellular repair machinery, often resulting in frameshift mutations that effectively inactivate the gene. This genetic modification enables scientists to assess the downstream effects of ZNF554 loss on cellular behavior, signal transduction pathways, and phenotypic changes, thus providing invaluable insights into its biological significance.
The scientific importance of ZNF554 knockout models extends to various fields, including cancer research, developmental biology, and therapeutic target identification. By elucidating the role of ZNF554 in pathology, researchers can pave the way for discovering novel biomarkers and therapeutic strategies. When comparing these specialized cell lines to traditional methods such as RNA interference, they offer enhanced specificity and reliability, with a more permanent and profound effect on gene function.
Moreover, ZNF554 Gene Knockout Cell Lines are valuable for both academic and clinical researchers seeking to unravel the complexities of gene function within a cellular framework. Their capacity to facilitate reproducible and high-throughput experiments makes them a preferred choice for those aiming to accelerate discovery and innovation in the life sciences.
New Horizons Biotechnology is committed to advancing biological research through the development of high-quality genetic models, such as the ZNF554 knockout cell lines, equipped with proven expertise in gene editing technologies and an understanding of researchers’ diverse needs. By choosing our products, clients gain access to a world of possibilities in genetic research, ultimately driving forward their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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