Gene: ZNF426
Official Full Name: zinc finger protein 426provided by HGNC
Gene Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12239 | ZNF426 Knockout cell line (HeLa) | Human | ZNF426 | 1:3~1:6 | Negative | Online Inquiry |
KO12240 | ZNF426 Knockout cell line (HCT 116) | Human | ZNF426 | 1:2~1:4 | Negative | Online Inquiry |
KO12241 | ZNF426 Knockout cell line (HEK293) | Human | ZNF426 | 1:3~1:6 | Negative | Online Inquiry |
KO12242 | ZNF426 Knockout cell line (A549) | Human | ZNF426 | 1:3~1:4 | Negative | Online Inquiry |
ZNF426 Gene Knockout Cell Lines are a specialized set of genetically modified cell lines that have been engineered to lack the expression of the ZNF426 gene, a crucial player in various cellular processes including gene regulation, differentiation, and apoptosis. By utilizing cutting-edge gene-editing technology such as CRISPR-Cas9, these cell lines allow researchers to investigate the physiological role of ZNF426 in cellular mechanisms and disease states, ultimately contributing to a deeper understanding of its functional significance in both normal and pathological contexts.
The primary mechanism of action involves the targeted disruption of the ZNF426 gene, which leads to a definitive loss of function. This process enables researchers to observe the consequences of gene knockout on cellular behaviors, such as proliferation, migration, and response to therapeutic agents. The ZNF426 knockout models are invaluable in elucidating its potential role as a tumor suppressor or oncogene, providing insights that could lead to innovative therapeutic strategies in treating various cancers and other diseases linked to aberrant gene function.
The scientific importance of ZNF426 Gene Knockout Cell Lines extends into both basic research and clinical applications. These cell lines facilitate the identification of new biological pathways associated with ZNF426 while also aiding drug discovery efforts aimed at targeting relevant signal transduction pathways. Researchers can leverage the knockout phenotype to explore compensatory cellular mechanisms, making these tools essential for understanding complex biological systems.
Compared to other gene knockout models, our ZNF426 Gene Knockout Cell Lines stand out due to their high specificity, reliability, and comprehensive characterization. We ensure that each cell line is validated for complete gene disruption and assessed for off-target effects, thereby guaranteeing that researchers can obtain reproducible and interpretable results with confidence.
Incorporating ZNF426 Gene Knockout Cell Lines into your research toolkit represents a significant step toward unraveling the complexities of gene function and disease mechanisms, ultimately supporting efforts to develop more effective therapies. Our company is dedicated to empowering researchers and clinicians with high-quality biological products backed by extensive expertise in genetic engineering, ensuring that you can trust in the integrity and performance of our offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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