Gene: ZNF185
Official Full Name: zinc finger protein 185 with LIM domainprovided by HGNC
Gene Summary: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34517 | ZNF185 Knockout cell line (HeLa) | Human | ZNF185 | 1:3~1:6 | Negative | Online Inquiry |
KO34518 | ZNF185 Knockout cell line (HCT 116) | Human | ZNF185 | 1:2~1:4 | Negative | Online Inquiry |
KO34519 | ZNF185 Knockout cell line (HEK293) | Human | ZNF185 | 1:3~1:6 | Negative | Online Inquiry |
KO34520 | ZNF185 Knockout cell line (A549) | Human | ZNF185 | 1:3~1:4 | Negative | Online Inquiry |
ZNF185 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed to elucidate the functions of the zinc finger protein 185 (ZNF185), a transcription factor implicated in various cellular processes, including gene expression regulation and chromatin remodeling. These genetically modified cell lines are crucial for researchers aiming to study the role of ZNF185 in cellular mechanisms and its potential contributions to diseases, such as cancer and neurological disorders.
Mechanistically, the ZNF185 gene knockout involves the targeted disruption of the ZNF185 locus using CRISPR-Cas9 technology, leading to a loss of function that allows for the investigation of resultant phenotypic changes. This approach facilitates the examination of ZNF185’s role in transcriptional control and its interactions with other proteins and genetic elements. Understanding these pathways can reveal new therapeutic targets and biomarker candidates for clinical applications.
The scientific significance of ZNF185 Gene Knockout Cell Lines extends to various research domains, including oncology, neurobiology, and developmental biology. They enable researchers to conduct functional assays, such as growth assays, differentiation studies, and gene expression analyses, providing invaluable insight into the gene’s role in pathological states.
Compared to alternative models like wild-type cell lines or animal models, ZNF185 knockout cells offer distinct advantages such as reduced biological variability, ease of use in high-throughput screening, and the ability to conduct rapid, reproducible experiments under controlled conditions. This specificity and adaptability make them an unparalleled resource for both academic and pharmaceutical research.
For researchers and clinicians, the value of ZNF185 Gene Knockout Cell Lines lies in their potential to drive novel discoveries and inform therapeutic strategies. Quality insights from these cell lines can lead to breakthroughs in understanding disease mechanisms and the development of innovative treatments.
Our company has extensive expertise in developing high-quality biological products and is committed to advancing research through innovative tools like the ZNF185 Gene Knockout Cell Lines, ensuring that scientists have access to the best resources for their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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