Gene: ZNF148
Official Full Name: zinc finger protein 148provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34585 | ZNF148 Knockout cell line (HeLa) | Human | ZNF148 | 1:3~1:6 | Negative | Online Inquiry |
KO34586 | ZNF148 Knockout cell line (HCT 116) | Human | ZNF148 | 1:2~1:4 | Negative | Online Inquiry |
KO34587 | ZNF148 Knockout cell line (HEK293) | Human | ZNF148 | 1:3~1:6 | Negative | Online Inquiry |
KO34588 | ZNF148 Knockout cell line (A549) | Human | ZNF148 | 1:3~1:4 | Negative | Online Inquiry |
ZNF148 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene disruption to inactivate the ZNF148 gene, which encodes a zinc finger protein implicated in various cellular processes including transcriptional regulation and chromatin remodeling. By utilizing the CRISPR-Cas9 gene-editing technology, these knockout cell lines allow researchers to investigate the role of ZNF148 in gene expression, differentiation, and cellular responses to environmental stimuli.
The primary mechanism by which these cell lines operate is the specific binding and silencing of target genes regulated by ZNF148. This disruption facilitates a deeper understanding of ZNF148’s involvement in crucial biological pathways, particularly those related to oncogenesis, cell cycle control, and epigenetic modifications. Researchers can utilize these knockout models to elucidate the mechanisms of disease, explore novel therapeutic targets, and validate drug efficacy, making them invaluable tools in both fundamental and applied biological research.
In clinical settings, ZNF148 gene knockout cell lines contribute to the growing body of knowledge in cancer research and regenerative medicine, offering insights into stem cell biology and tumor progression. The ability to generate reproducible and stable knockout models streamlines experiments and enhances the reliability of results. Moreover, these cell lines significantly reduce the time and resources required to create knockout models through traditional methods.
Compared to alternative approaches, such as RNA interference or traditional knockout mice, ZNF148 gene knockout cell lines provide a faster, cost-effective, and highly efficient means of gene disruption. This precision increases the ease with which researchers can manipulate cellular systems to draw meaningful conclusions about gene functions.
Our company, with its extensive expertise in creating advanced genetic tools and high-quality cell lines, is committed to supporting the scientific community. By providing ZNF148 Gene Knockout Cell Lines, we empower researchers and clinicians to push the boundaries of discovery, improve translational research, and ultimately contribute to the advancement of therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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