Gene: ZIC2
Official Full Name: Zic family member 2provided by HGNC
Gene Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34775 | ZIC2 Knockout cell line (HeLa) | Human | ZIC2 | 1:3~1:6 | Negative | Online Inquiry |
KO34776 | ZIC2 Knockout cell line (HCT 116) | Human | ZIC2 | 1:2~1:4 | Negative | Online Inquiry |
KO34777 | ZIC2 Knockout cell line (HEK293) | Human | ZIC2 | 1:3~1:6 | Negative | Online Inquiry |
KO34778 | ZIC2 Knockout cell line (A549) | Human | ZIC2 | 1:3~1:4 | Negative | Online Inquiry |
ZIC2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the functional ZIC2 gene, a critical regulator implicated in various developmental processes and neurological disorders. These cell lines utilize CRISPR-Cas9 technology to achieve precise gene editing, allowing for the study of ZIC2's role in gene expression regulation, cellular differentiation, and signal transduction pathways. By offering a complete knockout of ZIC2, these cell lines provide a robust platform for elucidating the gene's functional mechanisms and its involvement in pathophysiological conditions.
The significance of ZIC2 Gene Knockout Cell Lines lies in their application within both research and clinical settings. Researchers can investigate how the absence of ZIC2 affects cellular behaviors, including proliferation, apoptosis, and differentiation, thus gaining insights into developmental biology and the molecular underpinnings of disorders such as holoprosencephaly and autism spectrum disorders. Furthermore, these cell lines serve as valuable tools for drug discovery, allowing scientists to evaluate therapeutic interventions targeting pathways associated with ZIC2.
A notable advantage of ZIC2 Gene Knockout Cell Lines is their high specificity and reproducibility, which are critical for generating reliable data. Compared to alternative models, such as pharmacological inhibition or transient knockdown strategies, our knockout cell lines provide a stable and long-term experimental system that ensures consistent gene regulation assessment. This eliminates variability often seen with transient expression systems, making it easier for researchers to obtain interpretative results.
For researchers and clinicians alike, the value of ZIC2 Gene Knockout Cell Lines is accentuated by their ability to facilitate innovative boundary-pushing studies that may lead to breakthroughs in understanding genetic diseases and their treatments. Our company is dedicated to advancing biological research through high-quality gene editing tools and expertise, ensuring that our product offerings support cutting-edge discoveries in molecular and cell biology.
Please note that all services are for research use only. Not intended for any clinical use.
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