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ZFHX3 Knockout Cell Lines

Gene: ZFHX3

Official Full Name: zinc finger homeobox 3provided by HGNC

Gene Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06798 ZFHX3 Knockout cell line (HeLa) Human ZFHX3 1:3~1:6 Negative Online Inquiry
KO06799 ZFHX3 Knockout cell line (HCT 116) Human ZFHX3 1:2~1:4 Negative Online Inquiry
KO06800 ZFHX3 Knockout cell line (HEK293) Human ZFHX3 1:3~1:6 Negative Online Inquiry
KO06801 ZFHX3 Knockout cell line (A549) Human ZFHX3 1:3~1:4 Negative Online Inquiry

Background

ZFHX3 Gene Knockout Cell Lines are genetically modified cell models developed to specifically disrupt the ZFHX3 gene, a transcription factor implicated in various biological processes, including cell differentiation, development, and tumorigenesis. By utilizing CRISPR-Cas9 technology, these cell lines facilitate precise gene editing, resulting in the complete knockout of ZFHX3 expression. This disruption allows researchers to investigate the gene's specific roles in cellular mechanisms and disease models, providing insight into its contribution to development and pathology.

The key functions of ZFHX3 knockout cell lines include the ability to study gene regulatory networks, protein interactions, and the downstream effects of ZFHX3 loss on cellular behavior. Through this model, scientists can explore processes such as abnormal cell proliferation and differentiation, particularly in cancer research, where ZFHX3 has been shown to have oncogenic potential. By comparing wild-type and knockout cells, researchers can elucidate the molecular pathways affected by ZFHX3, thereby uncovering therapeutic targets for diseases linked to its dysregulation.

The scientific importance of these cell lines extends beyond basic research to clinical applications, as they serve as pivotal tools in drug development, biomarker discovery, and understanding disease mechanisms. With a continually growing body of research focusing on ZFHX3, leveraging knockout models accelerates the translation of fundamental findings into potential clinical therapies.

One of the unique selling points of our ZFHX3 Gene Knockout Cell Lines is the high efficiency of gene editing and reliability in maintaining stable knockout expression over time. Unlike alternative products that may utilize less precise gene-editing techniques, our offering provides researchers with a robust platform that ensures reproducible and interpretable results. This reliability is critical for high-stakes research endeavors and will facilitate smoother progression from discovery to application.

For researchers and clinicians, ZFHX3 Gene Knockout Cell Lines represent a valuable asset, allowing them to advance understanding in areas ranging from cancer biology to developmental disorders. With our team of experts experienced in gene editing technologies and a commitment to delivering high-quality biological products, our company is poised to support your research needs with cutting-edge solutions that empower scientific innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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