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ZBTB42 Knockout Cell Lines

Gene: ZBTB42

Official Full Name: zinc finger and BTB domain containing 42provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12478 ZBTB42 Knockout cell line (HeLa) Human ZBTB42 1:3~1:6 Negative Online Inquiry
KO12479 ZBTB42 Knockout cell line (HCT 116) Human ZBTB42 1:2~1:4 Negative Online Inquiry
KO12480 ZBTB42 Knockout cell line (HEK293) Human ZBTB42 1:3~1:6 Negative Online Inquiry
KO12481 ZBTB42 Knockout cell line (A549) Human ZBTB42 1:3~1:4 Negative Online Inquiry

Background

ZBTB42 Gene Knockout Cell Lines are innovative biological tools designed to facilitate the study of the ZBTB42 gene's role in cellular functions and disease mechanisms. The ZBTB42 gene encodes a zinc finger transcription factor that has been implicated in various biological processes, including immune response, differentiation, and oncogenesis. By employing CRISPR-Cas9 genome editing technology, these knockout cell lines effectively disable the ZBTB42 gene, allowing researchers to analyze the functional consequences of its loss in a controlled experimental setting.

The primary function of ZBTB42 Gene Knockout Cell Lines lies in providing a model system for elucidating the gene's involvement in critical signaling pathways and developmental processes. Researchers can utilize these cell lines to explore the mechanistic underpinnings of ZBTB42 in immune cell differentiation or its potential role in cancer progression. The knockout approach not only simplifies the identification of downstream targets but also enhances the understanding of gene interactions within complex biological systems.

In terms of scientific importance, these cell lines offer invaluable tools for both basic research and clinical applications, including drug discovery, cancer therapeutics, and understanding autoimmune disorders. Their usage can lead to the identification of novel therapeutic targets and biomarkers for disease, making them especially relevant in translational research.

Compared to traditional knockout strategies, our ZBTB42 Gene Knockout Cell Lines are meticulously validated for specificity and efficiency, ensuring reliable experimental outcomes. They are also readily available in various cellular backgrounds, enhancing their versatility for studies in different contexts.

Researchers and clinicians will find great value in adopting these knockout cell lines due to their potential to accelerate understanding of the ZBTB42 gene's role, which may unravel new pathways and ultimately contribute to improved therapeutic strategies. Our company, with its solid foundation in genetic engineering and commitment to advancing research tools, is proud to deliver high-quality products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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