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XXYLT1 Knockout Cell Lines

Gene: XXYLT1

Official Full Name: xyloside xylosyltransferase 1provided by HGNC

Gene Summary: Enables magnesium ion binding activity; manganese ion binding activity; and xylosyl alpha-1,3-xylosyltransferase activity. Involved in O-glycan processing. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21903 XXYLT1 Knockout cell line (HeLa) Human XXYLT1 1:3~1:6 Negative Online Inquiry
KO21904 XXYLT1 Knockout cell line (HCT 116) Human XXYLT1 1:2~1:4 Negative Online Inquiry
KO21905 XXYLT1 Knockout cell line (HEK293) Human XXYLT1 1:3~1:6 Negative Online Inquiry
KO21906 XXYLT1 Knockout cell line (A549) Human XXYLT1 1:3~1:4 Negative Online Inquiry

Background

XXYLT1 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the XXYLT1 gene, which encodes for a putative glycosyltransferase implicated in various cellular processes, including glycan synthesis and protein modification. These knockout cell lines serve as invaluable tools for researchers aiming to elucidate the functional roles of the XXYLT1 gene in cellular metabolism and disease pathways.

The primary mechanism of action relies on CRISPR-Cas9 technology, which introduces targeted mutations in the genomic sequence of the XXYLT1 gene, leading to a loss of function. This precise gene editing results in cells that lack the XXYLT1 protein, providing a clear advantage for studying the consequences of its absence on biological processes such as cell proliferation, differentiation, and signaling pathways. Such models enable scientists to draw connections between gene function, glycosylation patterns, and pathologies, including cancer and developmental disorders.

The scientific importance of XXYLT1 Gene Knockout Cell Lines is underscored by their application in both basic research and potential therapeutic innovations. In research settings, they are essential for functional studies that detail the implications of glycosylation in various diseases. Clinicians may also find these cell lines beneficial in testing therapeutic agents aimed at modulating glycan synthesis or directly targeting aberrant cellular functions linked to XXYLT1 dysregulation.

What sets these knockout cell lines apart from alternatives is not only their high specificity and efficiency but also the accompanying validation data demonstrating their reliability in diverse experimental setups. Using these cell lines provides researchers with robust models that reduce variability and enhance reproducibility in experimental outcomes.

For researchers and clinicians seeking to advance their understanding of glycan-related diseases or to develop novel therapeutic approaches, XXYLT1 Gene Knockout Cell Lines represent a critical asset. Our company specializes in producing high-quality biological products, ensuring that our customers receive not only rigorously validated models but also comprehensive support tailored to their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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