Gene: WWP2
Official Full Name: WW domain containing E3 ubiquitin protein ligase 2provided by HGNC
Gene Summary: This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31271 | WWP2 Knockout cell line (HeLa) | Human | WWP2 | 1:3~1:6 | Negative | Online Inquiry |
KO31272 | WWP2 Knockout cell line (HCT 116) | Human | WWP2 | 1:2~1:4 | Negative | Online Inquiry |
KO31273 | WWP2 Knockout cell line (HEK293) | Human | WWP2 | 1:3~1:6 | Negative | Online Inquiry |
KO31274 | WWP2 Knockout cell line (A549) | Human | WWP2 | 1:3~1:4 | Negative | Online Inquiry |
WWP2 Gene Knockout Cell Lines are genetically engineered cell lines wherein the WWP2 gene has been systematically inactivated through targeted genome editing techniques such as CRISPR-Cas9. By disrupting the expression of WWP2, a protein known to mediate pathways involved in cellular signaling, these cell lines provide a powerful tool for researchers investigating the role of WWP2 in various biological processes, including cell proliferation, differentiation, and apoptosis.
The primary mechanism through which these knockout cell lines operate involves the loss of function of the WWP2 protein, leading to altered downstream signaling cascades. This allows for detailed studies on how WWP2 influences critical cellular functions and its involvement in diseases, particularly those related to immune response and cancer. The availability of these cell lines is essential for both basic and applied research, facilitating the exploration of novel therapeutic strategies targeting WWP2-related pathways.
One of the significant advantages of the WWP2 Gene Knockout Cell Lines is their specificity and reliability in modeling WWP2-related biological functions. Unlike traditional methods that may rely on chemical inhibitors or RNA interference, which can exhibit off-target effects, these knockout models provide a clean, defined genetic background for more accurate studies. Additionally, these cell lines are versatile; they can be utilized in a range of applications, from high-throughput drug screening to in-depth mechanistic studies.
For researchers and clinicians, the availability of WWP2 Gene Knockout Cell Lines represents a critical asset, enhancing the ability to dissect complex cellular functions and develop targeted therapies. This data-driven approach not only accelerates the pace of discovery but also yields insights that can lead to innovative treatments for diseases linked to WWP2 dysregulation.
With extensive expertise in cellular biology and genetic engineering technologies, our company is committed to delivering high-quality biological products, including the WWP2 Gene Knockout Cell Lines. We strive to empower researchers with tools that enhance the understanding of biological mechanisms, ultimately contributing to advancements in biomedical sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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