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WWOX Knockout Cell Lines

Gene: WWOX

Official Full Name: WW domain containing oxidoreductaseprovided by HGNC

Gene Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00480 WWOX gRNA5-gRNA6 KO plasmid WWOX $850
GP00493 WWOX gRNA3-gRNA4 KO plasmid WWOX $850
KO01051 WWOX Knockout cell line (iPSC) Human WWOX 1:6-1:8 Negative Online Inquiry
KO12571 WWOX Knockout cell line (HeLa) Human WWOX 1:3~1:6 Negative Online Inquiry
KO12572 WWOX Knockout cell line (HCT 116) Human WWOX 1:2~1:4 Negative Online Inquiry
KO12573 WWOX Knockout cell line (HEK293) Human WWOX 1:3~1:6 Negative Online Inquiry
KO12574 WWOX Knockout cell line (A549) Human WWOX 1:3~1:4 Negative Online Inquiry

Background

WWOX Gene Knockout Cell Lines are genetically engineered cells designed to lack the functional WWOX gene, a critical suppressor of tumor formation and involved in various cellular processes like apoptosis, signal transduction, and metabolic regulation. These knockout cell lines serve as an invaluable tool for researchers studying the multifaceted roles of the WWOX gene in oncogenesis and other diseases.

Functionally, WWOX knockout cells provide a controlled environment to investigate the gene's involvement in biological pathways, enabling the study of cellular behaviors, gene interactions, and response to therapeutic agents. By utilizing these cell lines, researchers can examine how the loss of WWOX impacts proliferation, differentiation, and cellular response to stress or injury. This mechanistic insight is vital for understanding cancer biology, neurodegenerative diseases, and various metabolic disorders.

The scientific importance of WWOX knockout cell lines extends to both research and clinical applications. They facilitate the development of targeted therapies, biomarker discovery, and potentially the identification of new therapeutic approaches. Additionally, these cell lines can be utilized in drug screening assays, providing a platform to evaluate the efficacy of pharmaceutical compounds in a genetically defined context.

In comparison to alternative knockout models, WWOX Gene Knockout Cell Lines offer unparalleled specificity and reproducibility. Unlike transient knockdown methods, which can introduce variability and incomplete gene suppression, these stable cell lines ensure a complete and consistent loss of the WWOX gene. This feature enhances experimental precision, allowing for more reliable and interpretable data.

For researchers and clinicians focused on cancer biology, cell signaling, and therapeutic development, WWOX Gene Knockout Cell Lines are a valuable asset. Their use can streamline research processes and accelerate discoveries that bridge the gap from laboratory findings to practical clinical solutions.

At [Company Name], we are committed to advancing scientific knowledge through the provision of high-quality biological products. With a team of dedicated scientists and cutting-edge technologies, we proudly offer WWOX Gene Knockout Cell Lines, embodying our passion for supporting research that drives innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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