Gene: WRAP53
Official Full Name: WD repeat containing antisense to TP53provided by HGNC
Gene Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20981 | WRAP53 Knockout cell line (HeLa) | Human | WRAP53 | 1:3~1:6 | Negative | Online Inquiry |
KO20982 | WRAP53 Knockout cell line (HCT 116) | Human | WRAP53 | 1:2~1:4 | Negative | Online Inquiry |
KO20983 | WRAP53 Knockout cell line (HEK293) | Human | WRAP53 | 1:3~1:6 | Negative | Online Inquiry |
KO20984 | WRAP53 Knockout cell line (A549) | Human | WRAP53 | 1:3~1:4 | Negative | Online Inquiry |
WRAP53 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the WRAP53 gene, which plays a crucial role in several cellular processes, including telomere maintenance, gene expression regulation, and response to DNA damage. By employing CRISPR-Cas9 technology, these cell lines enable precise gene editing, allowing researchers to study the functional impact of WRAP53 loss in various biological contexts.
The key functions of WRAP53 align closely with its direct involvement in the assembly and stabilization of the shelterin complex, which protects telomeres—the protective caps on chromosome ends—thereby contributing to cellular aging and oncogenesis. With these knockout cell lines, scientists can elucidate the molecular pathways linked to telomere biology and their associations with diseases, including cancer and certain age-related disorders.
The scientific importance of WRAP53 Gene Knockout Cell Lines cannot be overstated, with applications ranging from basic research in molecular biology to translational studies in cancer therapeutics. These models offer unprecedented insights into the pathways affected by WRAP53, enhancing our understanding of tumorigenesis and enabling the development of targeted therapies aimed at restoring normal cellular function.
Distinct from conventional cell lines, WRAP53 Gene Knockout Cell Lines provide unparalleled specificity and insight into gene function, providing a unique selling point for researchers needing to validate their hypotheses with robust, genetically accurate models. The ability to use these cell lines in high-throughput screening and functional studies accelerates research timelines and fosters innovation in therapeutic strategies.
Given the pressing need for advanced cell models in modern biological research, WRAP53 Gene Knockout Cell Lines represent a valuable addition to the toolkit of researchers and clinicians alike. Our company specializes in providing high-quality, state-of-the-art biological products, driven by a commitment to advancing scientific knowledge and facilitating groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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