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WIZ Knockout Cell Lines

Gene: WIZ

Official Full Name: WIZ zinc fingerprovided by HGNC

Gene Summary: Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12590 WIZ Knockout cell line (HeLa) Human WIZ 1:3~1:6 Negative Online Inquiry
KO12591 WIZ Knockout cell line (HCT 116) Human WIZ 1:2~1:4 Negative Online Inquiry
KO12592 WIZ Knockout cell line (HEK293) Human WIZ 1:3~1:6 Negative Online Inquiry
KO12593 WIZ Knockout cell line (A549) Human WIZ 1:3~1:4 Negative Online Inquiry

Background

WIZ Gene Knockout Cell Lines are genetically engineered cell lines that have been developed to silence specific genes of interest through precise genomic editing techniques such as CRISPR-Cas9. This product serves as a vital toolkit for researchers seeking to study gene function, elucidate molecular pathways, and develop potential therapeutic strategies. The knockout mechanism involves the introduction of targeted double-strand breaks in the DNA, which are then repaired by non-homologous end joining, often resulting in mutations that disrupt gene expression.

The biological significance of WIZ Gene Knockout Cell Lines lies in their ability to provide insights into gene function and regulation, making them invaluable for both fundamental and applied research. In clinical settings, they can be instrumental in preclinical studies, drug development, and understanding the molecular basis of diseases. For example, researchers can employ these cell lines to investigate the role of oncogenes in cancer progression or to assess the therapeutic potential of novel drug compounds.

What sets WIZ Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene targeting, coupled with a range of customizable options that cater to diverse research needs. Unlike conventional knockdown methods, which may yield variable results, our knockout cell lines offer consistent genetic modification that is crucial for reproducibility in experimental design. Additionally, these cell lines come with characterized phenotypic profiles, thereby facilitating immediate application in studies.

By utilizing WIZ Gene Knockout Cell Lines, researchers and clinicians gain a powerful tool for advancing their work in genetics, cellular biology, and therapeutic development. Our expertise in genetic engineering and commitment to providing high-quality biological products ensures that you receive reliable resources to support your scientific endeavors. Trust in WIZ to enhance your research capabilities and drive innovations in your field.

Please note that all services are for research use only. Not intended for any clinical use.

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