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WASF1 Knockout Cell Lines

Gene: WASF1

Official Full Name: WASP family member 1provided by HGNC

Gene Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33718 WASF1 Knockout cell line (HeLa) Human WASF1 1:3~1:6 Negative Online Inquiry
KO33719 WASF1 Knockout cell line (HCT 116) Human WASF1 1:2~1:4 Negative Online Inquiry
KO33720 WASF1 Knockout cell line (HEK293) Human WASF1 1:3~1:6 Negative Online Inquiry
KO33721 WASF1 Knockout cell line (A549) Human WASF1 1:3~1:4 Negative Online Inquiry

Background

WASF1 Gene Knockout Cell Lines are scientifically engineered cellular models that facilitate the study of the WASF1 gene, which plays a critical role in actin cytoskeletal dynamics and cell motility pathways. These cell lines have been developed using advanced CRISPR-Cas9 gene-editing technology, allowing for precise and efficient disruption of the WASF1 gene. By eliminating its expression, researchers can investigate the resulting phenotypic alterations, contributing valuable insights into the gene’s biological functions and its implications in various cellular processes.

The key functions of the WASF1 gene knockout include the disruption of actin polymerization and subsequent modulation of cellular motility, adhesion, and signaling pathways. This makes these cell lines particularly useful for studies relating to cancer metastasis, immune response, and neurological conditions where WASF1 is implicated. The observation of altered cellular behaviors in these knockout models offers a robust platform for elucidating the molecular mechanisms underlying diseases and for screening potential therapeutic agents targeting cytoskeletal dynamics.

The scientific importance of WASF1 Gene Knockout Cell Lines extends beyond basic research, with potential applications in drug development and personalized medicine within clinical settings. These models offer a path to identify novel targets for therapeutic intervention in diseases characterized by abnormal cell migration and invasiveness.

What sets our WASF1 Gene Knockout Cell Lines apart from traditional models is their high specificity and reproducibility, which results from our rigorous validation processes. Furthermore, these cell lines are designed for ease of use and compatibility with various assay formats, providing researchers with versatile tools for their experimental needs.

Researchers and clinicians can derive immense value from employing WASF1 Gene Knockout Cell Lines in their studies—by utilizing a model that not only precisely represents the biological aberrations associated with WASF1 deficiency but also accelerates the discovery of novel insights into disease mechanisms and potential treatments.

At our company, we pride ourselves on our commitment to cutting-edge biotechnology and providing researchers with reliable and innovative solutions. We are dedicated to supporting advancements in health and science through our specialized genetic models, enabling breakthroughs across biological research fields.

Please note that all services are for research use only. Not intended for any clinical use.

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