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VKORC1L1 Knockout Cell Lines

Gene: VKORC1L1

Official Full Name: vitamin K epoxide reductase complex subunit 1 like 1provided by HGNC

Gene Summary: This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12678 VKORC1L1 Knockout cell line (HeLa) Human VKORC1L1 1:3~1:6 Negative Online Inquiry
KO12679 VKORC1L1 Knockout cell line (HCT 116) Human VKORC1L1 1:2~1:4 Negative Online Inquiry
KO12680 VKORC1L1 Knockout cell line (HEK293) Human VKORC1L1 1:3~1:6 Negative Online Inquiry
KO12681 VKORC1L1 Knockout cell line (A549) Human VKORC1L1 1:3~1:4 Negative Online Inquiry

Background

VKORC1L1 Gene Knockout Cell Lines represent a specialized biological tool designed for elucidating the functional roles of the VKORC1L1 gene in various biological processes and disease models. These engineered cell lines have been meticulously crafted using CRISPR-Cas9 gene-editing technology, ensuring precise removal of the VKORC1L1 gene, which is implicated in the regulation of vitamin K metabolism and anticoagulant responses. By providing a robust platform for studying the gene's effects on cellular behavior, these knockout cell lines facilitate in-depth investigation into signal transduction pathways and metabolic processes.

The primary mechanism by which VKORC1L1 knockout cell lines operate involves the disruption of protein synthesis related to vitamin K epoxide reductase, ultimately impacting coagulation processes and cellular responses to anticoagulants. Researchers can employ these cell lines to assess drug responses, explore gene interactions, and investigate pathophysiological conditions such as thrombosis or vitamin K deficiency. Their applications extend beyond basic research into potential clinical relevance, offering insights into personalized medicine approaches for managing coagulation disorders.

What sets VKORC1L1 Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. Unlike conventional cell lines that may carry redundant or compensatory mechanisms, these knockout lines provide a clean genetic background that allows researchers to directly observe phenotypic changes linked to VKORC1L1 loss. This specificity enhances the validity of experimental outputs, making these cell lines essential for generating reproducible and translatable scientific data.

For researchers and clinicians seeking to expand their knowledge on the genetic underpinnings of anticoagulation and related therapies, these knockout cell lines are invaluable. By delivering clear, actionable insights into gene function and drug response, they support the development of innovative therapeutic strategies and enable the refinement of treatment protocols.

Our company prides itself on its commitment to excellence in genetic engineering, offering cutting-edge bioresearch tools that empower scientists in their quest for discovery. With a focus on quality and precision, we are dedicated to advancing biological research through innovative product offerings, exemplified by our VKORC1L1 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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