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VDAC3 Knockout Cell Lines

Gene: VDAC3

Official Full Name: voltage dependent anion channel 3provided by HGNC

Gene Summary: This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08006 VDAC3 Knockout cell line (HeLa) Human VDAC3 1:3~1:6 Negative Online Inquiry
KO08007 VDAC3 Knockout cell line (HCT 116) Human VDAC3 1:2~1:4 Negative Online Inquiry
KO08008 VDAC3 Knockout cell line (HEK293) Human VDAC3 1:3~1:6 Negative Online Inquiry
KO08009 VDAC3 Knockout cell line (A549) Human VDAC3 1:3~1:4 Negative Online Inquiry

Background

VDAC3 Gene Knockout Cell Lines represent a significant advancement in the field of cellular and molecular biology, specifically designed to facilitate studies into mitochondrial functions and metabolic pathways. VDAC3, or Voltage-Dependent Anion Channel 3, is a vital component of the mitochondrial outer membrane, implicated in the transport of metabolites and ions, as well as in apoptotic signaling. The gene knockout approach effectively disables VDAC3 expression, allowing researchers to dissect its role in cellular processes and explore compensatory mechanisms in viability and energy metabolism.

The primary function of VDAC3 Gene Knockout Cell Lines is to serve as a tool for investigating the consequences of VDAC3 deficiency on cell physiology. By utilizing CRISPR-Cas9 technology, these cell lines achieve precise gene disruption, promoting an understanding of alterations in mitochondrial function, apoptosis regulation, and interactions with various cellular pathways. This detailed investigation can lead to groundbreaking insights into diseases associated with mitochondrial dysfunction, such as neurodegenerative disorders and metabolic syndromes.

In both research and clinical settings, VDAC3 Gene Knockout Cell Lines hold substantial importance. They can be applied in pharmacological testing to assess the impact of new therapeutic agents on mitochondria, aiding in drug discovery and development. Furthermore, they serve as vital models for highlighting the role of VDAC3 in cancer biology, thereby enhancing the understanding of tumor metabolism and therapeutic resistance.

Compared to other gene knockout models, VDAC3 Gene Knockout Cell Lines provide unique advantages such as high specificity and consistency across experimental replicates, enabling researchers to generate reproducible data. They also come ready for use in various applications, including high-throughput screening and metabolic profiling, which sets them apart from more labor-intensive alternatives requiring extensive preliminary work.

The value of VDAC3 Gene Knockout Cell Lines lies in their critical role in unraveling the complex biology of mitochondria, making them indispensable tools for researchers and clinicians focused on elucidating the mechanisms underpinning mitochondrial-related pathologies. Moreover, our company's extensive expertise in genomic technologies and commitment to advanced research solutions ensure that these cell lines meet the highest standards of quality and reliability, empowering scientists to push the boundaries of discovery in the biomedical field.

Please note that all services are for research use only. Not intended for any clinical use.

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