Gene: VAMP3
Official Full Name: vesicle associated membrane protein 3provided by HGNC
Gene Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33306 | VAMP3 Knockout cell line (HeLa) | Human | VAMP3 | 1:3~1:6 | Negative | Online Inquiry |
KO33307 | VAMP3 Knockout cell line (HCT 116) | Human | VAMP3 | 1:2~1:4 | Negative | Online Inquiry |
KO33308 | VAMP3 Knockout cell line (HEK293) | Human | VAMP3 | 1:3~1:6 | Negative | Online Inquiry |
KO33309 | VAMP3 Knockout cell line (A549) | Human | VAMP3 | 1:3~1:4 | Negative | Online Inquiry |
VAMP3 Gene Knockout Cell Lines are specialized cell models engineered to provide comprehensive insights into the functions and pathways regulated by the synaptic vesicle-associated membrane protein 3 (VAMP3). By employing advanced CRISPR-Cas9 gene editing techniques, these cell lines have been meticulously designed to disrupt the VAMP3 gene’s expression, allowing researchers to analyze the downstream effects of this specific knockout. The primary mechanism of action involves the loss of VAMP3, which plays a critical role in mediating vesicular transport and synaptic transmission; thus, its absence can significantly affect cellular communication processes.
The scientific importance of VAMP3 Gene Knockout Cell Lines lies in their diverse applications within research and clinical settings. They serve as vital tools in studying neurobiology, synaptic function, and cellular signaling pathways, making them invaluable for understanding neurodegenerative disorders, psychiatric conditions, and other neuromuscular diseases. Researchers can utilize these cell lines to uncover novel therapeutic targets, assess the effects of pharmacological agents, and explore fundamental biological processes pertinent to various diseases.
Compared to alternative cellular models, our VAMP3 Gene Knockout Cell Lines offer enhanced specificity and reproducibility, allowing for targeted experiments with precise control over genetic background influences. This precision makes them ideal for hypothesis-driven research while minimizing variability commonly found in traditional models. The unique selling points include the robustness of the CRISPR technology used for the knockout, alongside extensive validation demonstrating the functional impact of VAMP3 disruption on cellular behavior.
For researchers and clinicians focusing on the intricacies of synaptic functions and associated pathologies, these cell lines represent a powerful resource that not only facilitates cutting-edge experiments but also accelerates the translation of findings into clinical insights. Our commitment to excellence in genetic engineering ensures that our VAMP3 Gene Knockout Cell Lines stand backed by rigorous quality control and an established expertise in biological product development, making them the preferred choice for advancing your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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