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VAC14 Knockout Cell Lines

Gene: VAC14

Official Full Name: VAC14 component of PIKFYVE complexprovided by HGNC

Gene Summary: This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12708 VAC14 Knockout cell line (HeLa) Human VAC14 1:3~1:6 Negative Online Inquiry
KO12709 VAC14 Knockout cell line (HCT 116) Human VAC14 1:2~1:4 Negative Online Inquiry
KO12710 VAC14 Knockout cell line (HEK293) Human VAC14 1:3~1:6 Negative Online Inquiry
KO12711 VAC14 Knockout cell line (A549) Human VAC14 1:3~1:4 Negative Online Inquiry

Background

VAC14 Gene Knockout Cell Lines are specialized cellular models engineered to lack the VAC14 gene, which plays a critical role in regulating phosphoinositide signaling pathways. These knockout lines are invaluable tools for investigating the biological functions of VAC14, particularly in the context of cellular processes such as autophagy, cell division, and membrane trafficking. By creating deletion mutants of the VAC14 gene, researchers can observe the resultant phenotypic changes and gain insight into the molecular mechanisms underlying various physiological and pathological states.

The key function of VAC14 involves the modulation of phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2), which is essential for endosomal trafficking and lysosomal function. By utilizing VAC14 Gene Knockout Cell Lines, scientists can dissect the pathways that lead to altered cellular responses, offering a clear view of how VAC14 impacts cellular homeostasis and its role in diseases such as neurodegeneration and cancer.

The scientific importance of these cell lines is underscored by their applications in both basic and translational research. They provide a robust platform for drug discovery, biomarker development, and genetic studies, facilitating advances in understanding how disruptions in the VAC14 gene can lead to disease. Moreover, these cell lines open new avenues for the exploration of therapeutic interventions targeting the phosphoinositide signaling pathways.

The unique selling point of VAC14 Gene Knockout Cell Lines lies in their specificity and reliability. Unlike generic knockout models that may introduce unintended mutations, these lines are precisely engineered to ensure that the VAC14 knockout is both effective and reproducible. This precision allows for greater confidence in experimental outcomes, making them an essential addition to any research laboratory focused on cellular signaling and disease mechanisms.

For researchers and clinicians seeking to unravel the complexities of cellular pathways, VAC14 Gene Knockout Cell Lines offer a valuable asset for high-quality research. With extensive expertise in the production of innovative biological products, our company is dedicated to providing cutting-edge tools that empower the scientific community in its quest for knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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