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Usp7 Knockout Cell Lines

Gene: USP7

Official Full Name: ubiquitin specific peptidase 7provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01103 Usp7 Knockout cell line(BV2) Mouse Usp7 1:3~1:5 Negative Online Inquiry

Background

USP7 Gene Knockout Cell Lines are specialized cellular models developed to facilitate in-depth research into the role of the USP7 gene, which encodes a deubiquitinating enzyme crucial for regulating cellular processes such as DNA repair, signal transduction, and cell cycle progression. By effectively knocking out the USP7 gene, these cell lines provide researchers with a unique platform to dissect the molecular mechanisms and pathways influenced by USP7, thereby enhancing our understanding of its contributions to various biological phenomena.

The primary function of USP7 is to remove ubiquitin groups from specific target proteins, which can significantly alter protein stability and activity. This cellular manipulation allows researchers to observe the downstream effects of USP7 loss, including changes in gene expression profiles and cellular responses to stress, such as oncogenic transformations. Such insights are imperative for developing targeted therapies in cancer and other diseases where USP7 plays a pathological role.

The scientific importance of these knockout cell lines cannot be overstated. They serve as powerful tools for translational research, enabling studies on the pathophysiology of diseases like cancer and neurodegeneration. Furthermore, they provide critical data to pharmaceutical companies exploring novel therapeutic strategies that target USP7 or its associated pathways.

Compared to alternative models, USP7 Gene Knockout Cell Lines offer superior specificity and reproducibility, ensuring that researchers can obtain consistent results. These cell lines are validated for multiple downstream assays, including Western blotting, flow cytometry, and gene expression analysis, thus streamlining experimental workflows and yielding reliable data that researchers can trust.

This product is invaluable for researchers, clinicians, and biotechnologists, as it not only enhances our fundamental understanding of cellular processes but also paves the way for the development of next-generation therapeutics targeting USP7-related pathways. Our company remains at the forefront of biological innovations, providing high-quality gene knockout cell lines backed by extensive research and development expertise, ensuring that our customers have access to cutting-edge tools for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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