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USB1 Knockout Cell Lines

Gene: USB1

Official Full Name: U6 snRNA biogenesis phosphodiesterase 1provided by HGNC

Gene Summary: This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12764 USB1 Knockout cell line (HeLa) Human USB1 1:3~1:6 Negative Online Inquiry
KO12765 USB1 Knockout cell line (HCT 116) Human USB1 1:2~1:4 Negative Online Inquiry
KO12766 USB1 Knockout cell line (HEK293) Human USB1 1:3~1:6 Negative Online Inquiry
KO12767 USB1 Knockout cell line (A549) Human USB1 1:3~1:4 Negative Online Inquiry

Background

USB1 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of the USB1 gene's function, especially in contexts related to RNA processing and regulation. These cell lines have undergone targeted gene disruption to completely inactivate the USB1 gene, allowing researchers to investigate the biological consequences of this knockout in a controlled environment.

The cell lines function by offering an invaluable tool for elucidating the roles of USB1 in cellular processes such as RNA splicing, degradation, and overall gene expression regulation. By eliminating USB1 activity, researchers can analyze compensatory pathways, interactions with other molecular players, and downstream effects that influence both normal physiological functions and disease states. The mechanisms underlying these outcomes often reveal critical insights into the etiology of various illnesses, including certain malignancies or genetic disorders.

From a scientific standpoint, USB1 Gene Knockout Cell Lines are pivotal in advancing research into gene function and regulation. Their application in both basic research and therapeutic contexts enables nuanced explorations of genetic mechanisms, potentially leading to novel therapeutic targets. Furthermore, these cells are particularly advantageous for drug screening and validation as they provide a consistent background for assessing the impact of pharmacological agents or genetic modifications.

Compared to conventional knockdown strategies, which may leave residual gene activity, our USB1 knockout lines present the unique advantage of complete gene inactivation. This precision enhances the clarity and reliability of experimental outcomes. Additionally, these cell lines come with comprehensive support and extensive characterization data, empowering scientists to incorporate them into a wide range of experimental designs with confidence.

Given the increasing need for accurate models in molecular and cellular biology, USB1 Gene Knockout Cell Lines represent a valuable asset for researchers and clinicians striving to expand their understanding of gene function and therapeutic intervention. Our company specializes in high-quality biological products that empower scientific advancements and we are committed to providing exceptional resources and expertise to our clients.

Please note that all services are for research use only. Not intended for any clinical use.

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