Gene: UNC13D
Official Full Name: unc-13 homolog Dprovided by HGNC
Gene Summary: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02758 | UNC13D Knockout cell line (HeLa) | Human | UNC13D | 1:3~1:6 | Negative | Online Inquiry |
KO02759 | UNC13D Knockout cell line (HCT 116) | Human | UNC13D | 1:2~1:4 | Negative | Online Inquiry |
KO02760 | UNC13D Knockout cell line (A549) | Human | UNC13D | 1:3~1:4 | Negative | Online Inquiry |
UNC13D Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the expression of the UNC13D gene, a critical component in the regulation of synaptic transmission and membrane fusion processes. This innovative product provides researchers with a powerful tool for studying the role of UNC13D in various biological contexts, particularly in the elucidation of its impact on immune responses and synaptic function.
The primary function of these knockout cell lines is to serve as a model system to investigate the physiological and pathological roles of UNC13D. The knockout is achieved using CRISPR-Cas9 gene editing technology, which allows for precise and efficient gene disruption. By observing the resulting phenotypic changes in cell signaling, researchers can gain insights into the gene's role in diseases such as hemophagocytic lymphohistiocytosis (HLH) and other immune-related disorders.
The scientific importance of UNC13D Gene Knockout Cell Lines extends to foundational research and therapeutic applications. In clinical settings, understanding the mechanistic pathways involving UNC13D can pave the way for novel interventions in immune regulation, paving the way for targeted therapies that improve patient outcomes.
Compared to conventional cell lines that express UNC13D, these knockout models provide a unique perspective by eliminating confounding variables associated with gene expression, thus facilitating clearer interpretation of experimental results. This specificity allows researchers to focus on the consequences of UNC13D deficiency without the noise of other interacting pathways.
For researchers and clinicians, the value of UNC13D Gene Knockout Cell Lines lies in their ability to streamline experimental processes and enhance the accuracy of investigations involving immune function and neurological signaling. With comprehensive support and expertise in genetic engineering, our company stands at the forefront of innovation in biological products, ensuring that our offerings meet the rigorous demands of scientific inquiry and clinical research.
Please note that all services are for research use only. Not intended for any clinical use.
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