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UGP2 Knockout Cell Lines

Gene: UGP2

Official Full Name: UDP-glucose pyrophosphorylase 2provided by HGNC

Gene Summary: The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03213 UGP2 Knockout cell line (HeLa) Human UGP2 1:3~1:6 Negative Online Inquiry
KO03214 UGP2 Knockout cell line (HCT 116) Human UGP2 1:2~1:4 Negative Online Inquiry
KO03215 UGP2 Knockout cell line (HEK293) Human UGP2 1:3~1:6 Negative Online Inquiry
KO03216 UGP2 Knockout cell line (A549) Human UGP2 1:3~1:4 Negative Online Inquiry

Background

UGP2 Gene Knockout Cell Lines are engineered cellular models in which the UGP2 gene is functionally disrupted, allowing for detailed study of its role in cellular metabolism and physiological processes. These cell lines serve as invaluable tools for researchers investigating glycogen metabolism, nucleotide sugar biosynthesis, and cellular energy homeostasis. The knockout of the UGP2 gene results in the absence of the enzyme that catalyzes the conversion of glucose-1-phosphate to UDP-glucose, a crucial substrate for various biosynthetic pathways, hence dramatically influencing cellular metabolism.

The primary mechanism by which these cell lines operate is through the complete loss of UGP2 function, providing a controlled environment to examine compensatory metabolic pathways and evaluate the role of UGP2 in health and disease. Researchers can utilize these models to explore the implications of UGP2 deficiency in metabolic disorders, cancer biology, and development.

The scientific importance of UGP2 Gene Knockout Cell Lines is underscored by their applications in both fundamental research and clinical studies. By employing these cell lines, scientists can elucidate the molecular mechanisms underlying various metabolic diseases and assess the potential therapeutic approaches for correcting UGP2-related deficiencies. Moreover, these models facilitate high-throughput screening of pharmacological agents targeting related metabolic pathways.

One significant advantage of our UGP2 Gene Knockout Cell Lines is their high fidelity and reproducibility, resulting from rigorous validation processes. Compared to other models, these knockout lines offer a more precise assessment of UGP2 function, eliminating confounding variables often present in less specific models, such as partial knockdowns or overexpressed endogenous variants.

Our UGP2 Gene Knockout Cell Lines provide exceptional value to researchers and clinicians alike by enabling the dissection of complex metabolic networks and the development of targeted therapeutic strategies. By investing in these advanced cellular models, users gain access to an innovative solution that enhances research outcomes and accelerates discoveries in metabolic health.

As a company committed to advancing the field of biological research, we leverage our expertise in genetic engineering and cell line development to deliver high-quality products that facilitate cutting-edge science and empower researchers to achieve their goals.

Please note that all services are for research use only. Not intended for any clinical use.

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