Gene: UCKL1
Official Full Name: uridine-cytidine kinase 1 like 1provided by HGNC
Gene Summary: The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20649 | UCKL1 Knockout cell line (HeLa) | Human | UCKL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20650 | UCKL1 Knockout cell line (HCT 116) | Human | UCKL1 | 1:2~1:4 | Negative | Online Inquiry |
KO20651 | UCKL1 Knockout cell line (HEK293) | Human | UCKL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20652 | UCKL1 Knockout cell line (A549) | Human | UCKL1 | 1:3~1:4 | Negative | Online Inquiry |
UCKL1 Gene Knockout Cell Lines are genetically modified cell lines designed to facilitate the study of UCKL1 (Uridine-Cytidine Kinase-Like 1), a critical gene implicated in various biological processes, including nucleotide metabolism and cellular stress responses. These knockout cell lines enable researchers to investigate the functional role of UCKL1 by observing phenotypic and molecular changes that occur in its absence.
The primary mechanism of action involves the targeted disruption of the UCKL1 gene through CRISPR-Cas9 or similar gene-editing technologies, resulting in loss-of-function mutations that provide insight into the gene's biological significance. By utilizing these knockout cell lines, scientists can analyze alterations in cell proliferation, metabolism, and signaling pathways, which are vital for understanding both normal cellular functions and pathological conditions.
From a scientific perspective, UCKL1 gene knockout cell lines hold considerable importance in developmental biology, cancer research, and therapeutic development. Their applications extend to investigating the role of UCKL1 in drug resistance, cellular differentiation, and responses to environmental stressors, making them a valuable tool for advancing both basic research and translational studies.
Compared to alternative methodologies, such as traditional siRNA-based approaches, knockout cell lines provide a more stable and permanent modification, allowing for long-term studies and reliable data generation. Researchers benefit from the reproducibility and specificity of studying genetic effects without the transient interference associated with RNA interference techniques.
For researchers and clinicians alike, the UCKL1 gene knockout cell lines represent an essential resource for unraveling complex biological questions associated with UCKL1. They not only enable groundbreaking discoveries but also support the pursuit of targeted therapies that can address diseases caused by UCKL1 dysfunction.
With years of experience in developing advanced genomic products, our company prides itself on delivering high-quality, innovative solutions that empower researchers in their scientific pursuits. Our expertise ensures that UCKL1 gene knockout cell lines meet rigorous quality standards, providing reliable tools for pushing the boundaries of genetic research.
Please note that all services are for research use only. Not intended for any clinical use.
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