Gene: UCK1
Official Full Name: uridine-cytidine kinase 1provided by HGNC
Gene Summary: This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25458 | UCK1 Knockout cell line (HeLa) | Human | UCK1 | 1:3~1:6 | Negative | Online Inquiry |
KO25459 | UCK1 Knockout cell line (HCT 116) | Human | UCK1 | 1:2~1:4 | Negative | Online Inquiry |
KO25460 | UCK1 Knockout cell line (HEK293) | Human | UCK1 | 1:3~1:6 | Negative | Online Inquiry |
KO25461 | UCK1 Knockout cell line (A549) | Human | UCK1 | 1:3~1:4 | Negative | Online Inquiry |
UCK1 Gene Knockout Cell Lines represent a pivotal advancement in the field of genetic research. These specialized cell lines are engineered to lack the expression of the uridine-cytidine kinase 1 (UCK1) gene, a vital component in the nucleoside metabolism pathway. UCK1 plays a crucial role in the phosphorylation of uridine and cytidine, making this knockout model invaluable for studying nucleotide metabolism, drug efficacy, and cellular response mechanisms in various pathological conditions.
Functionally, UCK1 knockout cell lines allow researchers to observe the effects of UCK1 deficiency on cellular activities, including proliferation, apoptosis, and metabolic adaptations. By utilizing these cell lines, scientists can dissect the role of UCK1 in various cellular contexts and evaluate how its absence influences cellular homeostasis, thereby providing insights into diseases like cancer and metabolic disorders.
The scientific importance of UCK1 knockout cell lines extends to both research and clinical applications. They are critical for validating the therapeutic potential of drugs targeting nucleoside metabolism and can serve as a platform for screening novel compounds in high-throughput drug discovery environments. Furthermore, understanding UCK1's role can enhance the development of biomarker-based strategies for personalized medicine, particularly in cancer treatments that rely on nucleotide analogs.
One of the unique selling points of our UCK1 Gene Knockout Cell Lines is their high specificity and reproducibility, ensuring that researchers can obtain consistent results across experiments. Unlike conventional models that might have off-target effects or variations, our knockout lines provide a clean genetic background for more reliable data interpretation. Moreover, they are compatible with a variety of assays, including cell proliferation, drug sensitivity, and gene expression analysis, making them versatile tools for investigators.
For researchers and clinicians keen on advancing their understanding of nucleotide metabolism and its implications in health and disease, UCK1 Gene Knockout Cell Lines offer an exceptional resource. Our company's expertise in genetic engineering and commitment to quality ensures that you receive reliable, cutting-edge products designed to meet your research needs, empowering you to uncover the intricacies of biological systems effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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