Gene: UBN1
Official Full Name: ubinuclein 1provided by HGNC
Gene Summary: Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27014 | UBN1 Knockout cell line (HeLa) | Human | UBN1 | 1:3~1:6 | Negative | Online Inquiry |
KO27015 | UBN1 Knockout cell line (HCT 116) | Human | UBN1 | 1:2~1:4 | Negative | Online Inquiry |
KO27016 | UBN1 Knockout cell line (HEK293) | Human | UBN1 | 1:3~1:6 | Negative | Online Inquiry |
KO27017 | UBN1 Knockout cell line (A549) | Human | UBN1 | 1:3~1:4 | Negative | Online Inquiry |
UBN1 Gene Knockout Cell Lines are specifically engineered cellular models designed to silence the UBN1 gene, which plays a critical role in diverse biological processes, including DNA repair and chromatin remodeling. These cell lines facilitate the investigation of UBN1's function and its impact on cellular physiology, enabling researchers to explore the underlying mechanisms of diseases related to genomic instability and cancer pathology.
The UBN1 knockout process is executed using CRISPR-Cas9 technology, which allows for precise deletion of the gene, thus providing a definitive model to study the gene's contribution to cellular functions. By observing the phenotypic and molecular changes in these cell lines, researchers can gather valuable insights into the UBN1 gene's role in key biological pathways, such as cell cycle regulation and response to DNA damage. This powerful tool is essential for advancing our understanding of the UBN1 gene's implications in both therapeutic contexts and basic biological research.
In clinical settings, UBN1 Gene Knockout Cell Lines serve as a platform for drug discovery and development, particularly in identifying potential therapeutic targets for cancers associated with UBN1 dysregulation. Their use can accelerate the identification of new pharmacological agents aimed at modulating UBN1-related pathways, making them vital for translational research.
What sets our UBN1 Gene Knockout Cell Lines apart is their exceptional specificity and reproducibility. Unlike alternative models, which may produce off-target effects or variable expression levels, our knockout lines offer consistent genetic alterations that facilitate robust experimental control. This allows researchers to generate high-quality, reliable data, ultimately leading to breakthroughs in understanding disease mechanisms and treatment strategies.
For researchers and clinicians alike, the UBN1 Gene Knockout Cell Lines present an invaluable resource for dissecting complex biological interactions and developing effective therapeutic interventions. Our company prides itself on providing high-quality biological products and expertise, ensuring that you have access to the best tools for advancing your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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