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UBE2L6 Knockout Cell Lines

Gene: UBE2L6

Official Full Name: ubiquitin conjugating enzyme E2 L6provided by HGNC

Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33418 UBE2L6 Knockout cell line (HCT 116) Human UBE2L6 1:2~1:4 Negative Online Inquiry
KO33419 UBE2L6 Knockout cell line (HEK293) Human UBE2L6 1:3~1:6 Negative Online Inquiry
KO33420 UBE2L6 Knockout cell line (A549) Human UBE2L6 1:3~1:4 Negative Online Inquiry

Background

UBE2L6 Gene Knockout Cell Lines are specialized cellular models engineered for the targeted disruption of the UBE2L6 gene, which encodes an E2 ubiquitin-conjugating enzyme playing a vital role in protein regulation and degradation involved in numerous cellular processes, including responses to stress and inflammation. These cell lines enable researchers to study the effects of UBE2L6 silencing on cellular mechanisms, providing insights into various biological pathways, particularly those related to innate immunity and cancer biology.

The primary function of UBE2L6 Gene Knockout Cell Lines is to facilitate the dissection of UBE2L6's molecular interactions and its impact on cellular behavior. By utilizing CRISPR/Cas9 technology, these knockout cell lines induce precise genetic alterations, allowing for the observation of phenotypic changes and altered signaling cascades. Researchers can assess how the absence of UBE2L6 influences processes such as apoptosis, autophagy, and protein stability, crucial for understanding complex diseases and developing targeted therapeutics.

Scientifically, these cell lines are invaluable in both research and clinical settings, offering a robust platform to uncover the biological roles of UBE2L6 in health and disease. They can be utilized in drug discovery and validation studies, particularly in cancer therapeutics, where modulation of ubiquitin pathways may enhance treatment efficacy or reduce resistance.

Key advantages of UBE2L6 Gene Knockout Cell Lines include their precision, reproducibility, and the ability to seamlessly integrate with various downstream applications, such as RNA sequencing, proteomics, and high-throughput screening. Unlike traditional knockdown approaches, these knockout models provide a permanent genetic alteration, yielding clearer results and insights into gene function over time.

For researchers and clinicians, the value of UBE2L6 Gene Knockout Cell Lines cannot be overstated. They represent a pioneering tool for elucidating mechanistic pathways and validating novel therapeutic targets, ultimately contributing to the advancement of precision medicine.

Our company has extensive expertise in developing cutting-edge genetic tools and adheres to rigorous scientific standards, ensuring that our UBE2L6 Gene Knockout Cell Lines meet the high expectations of the research community and enhance the understanding of gene function in disease models.

Please note that all services are for research use only. Not intended for any clinical use.

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